tau Proteins - Metabolism
Research News and Information

Sunday, November 22, 2009

Phospholipid transfer protein reduces phosphorylation of tau in human neuronal cells.

30 Oct 2009 Tau function is regulated by phosphorylation, and abnormal tau phosphorylation in neurons is one of the key processes associated with development of Alzheimer's disease and other tauopathies. In this study we provide evidence that phospholipid ... Read more...

Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations.

12 Oct 2009 In Alzheimer's disease (AD), rod-like cofilin aggregates (cofilin-actin rods) and thread-like inclusions containing phosphorylated microtubule-associated protein (pMAP) tau form in the brain (neuropil threads), and the extent of their presence ... Read more...

Axonal transport defects in neurodegenerative diseases.

12 Oct 2009 Adult-onset neurodegenerative diseases (AONDs) comprise a heterogeneous group of neurological disorders characterized by a progressive, age-dependent decline in neuronal function and loss of selected neuronal populations. Alterations in synaptic ... Read more...

Latest indexed articles for 'tau Proteins - Metabolism'

These are the very latest articles for this heading:

• Phospholipid transfer protein reduces phosphorylation of tau in human neuronal cells. 30 Oct 2009
• Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. 12 Oct 2009
• Axonal transport defects in neurodegenerative diseases. 12 Oct 2009
• Addressing Alzheimer's disease tangles: from NAP to AL-108. 29 Sep 2009
• O-GlcNAc modification and the tauopathies: insights from chemical biology. 29 Sep 2009
• Lysosomal modulatory drugs for a broad strategy against protein accumulation disorders. 29 Sep 2009
• Modulation and detection of tau aggregation with small-molecule ligands. 29 Sep 2009
• Nature of "Tau" immunoreactivity in normal myonuclei and inclusion body myositis. 29 Sep 2009
• Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. 29 Sep 2009
• Novel therapeutics based on tau/microtubule dynamics: WO2008084483. 30 Aug 2009
• Laminar distribution of the pathological changes in frontal and temporal cortex in 8 patients with progressive supranuclear palsy. 30 Aug 2009
• Selective deposition of 4-repeat tau in cerebral infarcts. 30 Aug 2009
• Function of tau protein in adult newborn neurons. 16 Aug 2009
• Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening. 16 Aug 2009
• Repression of tau hyperphosphorylation by chronic endurance exercise in aged transgenic mouse model of tauopathies. 13 Aug 2009
• Natural lipophilic inhibitors of mitochondrial complex I are candidate toxins for sporadic neurodegenerative tau pathologies. 11 Aug 2009
• Alpha-synuclein immunopositive aggregates in the myenteric plexus of the aging Fischer 344 rat. 3 Aug 2009
• Linking amyloid and tau pathology in Alzheimer's disease: the role of membrane cholesterol in Abeta-mediated tau toxicity. 3 Aug 2009
• Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport. Aug 2009
• Phosphorylation of more than one site is required for tight interaction of human tau protein with 14-3-3zeta. Aug 2009

See a longer list of these articles.

Technical information about 'tau Proteins'

Definition: Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).

Registry Number: 0

Descriptor UI: D016875

Alternative terms: tau Proteins; Proteins, tau; tau Protein; Protein, tau;

Related Mesh Headings: Tauopathies;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.220.600.450.510; D12.776.641.560.510;

Online Note: use TAU PROTEINS (NM) to search TAU (NM) 1980-90

History Note: 1992; use TAU (NM) 1977-91