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tau Proteins
Research News and Information
Definition of 'tau Proteins'Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES). |
Sunday, November 22, 2009
Biomarkers in the cerebrospinal fluid and neurodegeneration in Langerhans cell histiocytosis.
13 Dec 2009 
BACKGROUND: Progressive neurodegeneration may result in potentially severe cognitive and motor dysfunctions as a complication of Langerhans cell histiocytosis (LCH), a suggested IL-17A-associated inflammatory condition. To detect this complication ... Read more...
The heritability and genetics of frontotemporal lobar degeneration.
Nov 2009 BACKGROUND: Frontotemporal lobar degeneration (FTLD) is a genetically and pathologically heterogeneous neurodegenerative disorder. METHODS: We collected blood samples from a cohort of 225 patients with a diagnosis within the FTLD spectrum and ... Read more...
Two distinct subtypes of right temporal variant frontotemporal dementia.
Nov 2009 BACKGROUND: Right temporal frontotemporal dementia (FTD) is an anatomic variant of FTD associated with relatively distinct behavioral and cognitive symptoms. We aimed to determine whether right temporal FTD is a homogeneous clinical, imaging, and ... Read more...
Latest indexed articles for 'tau Proteins'
These are the very latest articles for this heading:
- Biomarkers in the cerebrospinal fluid and neurodegeneration in Langerhans cell histiocytosis. 13 Dec 2009
- The heritability and genetics of frontotemporal lobar degeneration. Nov 2009
- Two distinct subtypes of right temporal variant frontotemporal dementia. Nov 2009
- Phospholipid transfer protein reduces phosphorylation of tau in human neuronal cells. 30 Oct 2009
- Alzheimer's biomarker initiative hits its stride.
14 Oct 2009 - Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. 12 Oct 2009
- Axonal transport defects in neurodegenerative diseases. 12 Oct 2009
- Relationships between biomarkers in aging and dementia. 11 Oct 2009
- Addressing Alzheimer's disease tangles: from NAP to AL-108. 29 Sep 2009
- O-GlcNAc modification and the tauopathies: insights from chemical biology. 29 Sep 2009
- Tau-focused immunotherapy for Alzheimer's disease and related tauopathies. 29 Sep 2009
- Lysosomal modulatory drugs for a broad strategy against protein accumulation disorders. 29 Sep 2009
- Modulation and detection of tau aggregation with small-molecule ligands. 29 Sep 2009
- Nature of "Tau" immunoreactivity in normal myonuclei and inclusion body myositis. 29 Sep 2009
- Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. 29 Sep 2009
- Chemical manipulation of hsp70 ATPase activity regulates tau stability. 28 Sep 2009
- Atrophy patterns in IVS10+16, IVS10+3, N279K, S305N, P301L, and V337M MAPT mutations. 27 Sep 2009
- Baseline CSF p-tau levels independently predict progression of hippocampal atrophy in Alzheimer disease. 20 Sep 2009
- Low-power solid-state NMR experiments for resonance assignment under fast magic-angle spinning. 12 Sep 2009
- Novel therapeutics based on tau/microtubule dynamics: WO2008084483. 30 Aug 2009
See a longer list of these articles.
Technical information about 'tau Proteins'
Definition: Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).
Registry Number: 0
Descriptor UI: D016875
Alternative terms: tau Proteins; Proteins, tau; tau Protein; Protein, tau;
Related Mesh Headings: Tauopathies;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D12.776.220.600.450.510; D12.776.641.560.510;
Online Note: use TAU PROTEINS (NM) to search TAU (NM) 1980-90
History Note: 1992; use TAU (NM) 1977-91