Telomere - Metabolism
Research News and Information

Wednesday, March 17, 2010

Telomere aggregate formation in placenta specimens of pregnancies complicated with pre-eclampsia.

30 Oct 2009 Telomeres are specific repetitive DNA sequences that cap and stabilize the ends of chromosomes. Functional telomeres are essential for the normal segregation and maintenance of chromosomes during mitotic and meiotic division. Pre-eclampsia, a ... Read more...

Cohesin SMC1beta protects telomeres in meiocytes.

17 Oct 2009 Meiosis-specific mammalian cohesin SMC1beta is required for complete sister chromatid cohesion and proper axes/loop structure of axial elements (AEs) and synaptonemal complexes (SCs). During prophase I, telomeres attach to the nuclear envelope (NE), ... Read more...

Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells.

10 Oct 2009 Replicated sister chromatids are held together until mitosis by cohesin, a conserved multisubunit complex comprised of Smc1, Smc3, Scc1, and Scc3, which in vertebrate cells exists as two closely related homologues (SA1 and SA2). Here, we show that ... Read more...

Latest indexed articles for 'Telomere - Metabolism'

These are the very latest articles for this heading:

• Telomere aggregate formation in placenta specimens of pregnancies complicated with pre-eclampsia. 30 Oct 2009
• Cohesin SMC1beta protects telomeres in meiocytes. 17 Oct 2009
• Differential regulation of telomere and centromere cohesion by the Scc3 homologues SA1 and SA2, respectively, in human cells. 10 Oct 2009
• The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells. 10 Oct 2009
• Chromosome protection scoops Nobel. 6 Oct 2009
• Connecting obesity, aging and diabetes. 30 Aug 2009
• Breaks invisible to the DNA damage response machinery accumulate in ATM-deficient cells. 30 Aug 2009
• Short telomeres are preferentially elongated by telomerase in human cells. 27 Aug 2009
• TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres. 26 Aug 2009
• Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination. 24 Aug 2009
• Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. 24 Aug 2009
• Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance. 12 Aug 2009
• The SAGA continues...to the end. 12 Aug 2009
• Functional interplay between Parp-1 and SirT1 in genome integrity and chromatin-based processes. 10 Aug 2009
• A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. 7 Aug 2009
• Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells. 5 Aug 2009
• Human telomerase caught in the act. 5 Aug 2009
• POT1 association with TRF2 regulates telomere length. Aug 2009
• Histone H3 N-terminus regulates higher order structure of yeast heterochromatin. Aug 2009
• OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Telomere'

Definition: A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. Its length is believed to be a few hundred base pairs.

Descriptor UI: D016615

Alternative terms: Telomere; Telomeres;

Allowable Qualifiers: classification; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; transplantation; ultrastructure; ultrasonography; chemistry; virology; genetics;

Tree Number: A11.284.430.106.279.345.190.160.845; G05.360.160.845;

History Note: 92

Technical Notes: terminal section of a chromosome involved in chromosomal replication & stability; A 11 qualif except /cytol; /genet permitted