Temazepam - Pharmacokinetics
Research News and Information

Monday, November 23, 2009

Impact of melatonin, zaleplon, zopiclone, and temazepam on psychomotor performance.

29 Nov 2003 INTRODUCTION: Modern military operations may require pharmaceutical methods to sustain alertness and facilitate sleep in order to maintain operational readiness. In operations with very limited sleep windows, hypnotics with very short half-lives ... Read more...

[Comparative kinetics of 3-hydroxyphenazepam and its metabolism during transdermal and intravenous administration]

29 Apr 2003 The kinetics of excretion of 2-(14)C-3-hydroxyphenazepam and its metabolites were studied upon a single transdermal and intravenous administration in mice. The main fraction of the total radioactivity (approximately 80%) was eliminated within ... Read more...

Mechanism of increased dissolution of diazepam and temazepam from polyethylene glycol 6000 solid dispersions.

3 Dec 2002 Solid dispersion literature, describing the mechanism of dissolution of drug-polyethylene glycol dispersions, still shows some gaps; (A). only few studies include experiments evaluating solid solution formation and the particle size of the drug in ... Read more...

Latest indexed articles for 'Temazepam - Pharmacokinetics'

These are the very latest articles for this heading:

• Fatigue countermeasures and the use of hypnotics in aircrew. 30 Mar 2009
• CNS effects of sumatriptan and rizatriptan. 30 Dec 2003
• Impact of melatonin, zaleplon, zopiclone, and temazepam on psychomotor performance. 29 Nov 2003
• [Comparative kinetics of 3-hydroxyphenazepam and its metabolism during transdermal and intravenous administration] 29 Apr 2003
• Mechanism of increased dissolution of diazepam and temazepam from polyethylene glycol 6000 solid dispersions. 3 Dec 2002
• CNS effects of sumatriptan and rizatriptan in healthy female volunteers. 29 Apr 2002
• Comparison of the rates of hydrolysis of lorazepam-glucuronide, oxazepam-glucuronide and tamazepam-glucuronide catalyzed by E. coli beta-D-glucuronidase using the on-line benzodiazepine screening immunoassay on the Roche/Hitachi 917 analyzer. 27 Feb 2001
• Drug release from an ensemble of swellable crosslinked polymer particles. 29 Jul 2000
• Efficacy of activated charcoal versus gastric lavage half an hour after ingestion of moclobemide, temazepam, and verapamil. 29 Jun 2000
• A study of the effects of long-term use on individual sensitivity to temazepam and lorazepam in a clinical population. 30 Aug 1997
• Site-to-site variability of drug concentrations in skeletal muscle. 30 Aug 1997
• Site to site variability of postmortem drug concentrations in liver and lung. 30 Oct 1996
• Pharmacokinetic aspects of rectal formulations of temazepam. 30 May 1996
• Lack of effect of antimycotic itraconazole on the pharmacokinetics or pharmacodynamics of temazepam. 30 Mar 1996
• Pharmacokinetics of temazepam in male surgical patients. 30 Jul 1995
• Concentration-dependent metabolism of diazepam in mouse liver. 30 May 1995
• Drug accumulation and elimination in Calliphora vicina larvae. 26 Feb 1995
• Lack of interaction of erythromycin with temazepam. 29 Nov 1994
• Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms. 30 Jul 1994
• The influence of ciprofloxacin on the pharmacokinetics and pharmacodynamics of a single dose of temazepam in the young and elderly. 30 Mar 1994

See a longer list of these articles.

Technical information about 'Temazepam'

Definition: A benzodiazepine that acts as a GAMMA-AMINOBUTYRIC ACID modulator and anti-anxiety agent.

Chemical name: 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-

Registry Number: 846-50-4

Descriptor UI: D013693

Alternative terms: Temazepam; Oxydiazepam; Methyloxazepam; 3-Hydroxydiazepam; 3 Hydroxydiazepam; Hydroxydiazepam; Dasuen; Knoll Brand of Temazepam; Euhypnos; Planum; Sigma Brand of Temazepam; Pharmacia Brand of Temazepam; Gen-Temazepam; Gen Temazepam; Genpharm Brand of Temazepam; Levanxol; Norkotral Tema; Tema, Norkotral; Desitin Brand of Temazepam; Normison; Wyeth Brand of Temazepam; Nocturne; Temtabs; AHP Brand of Temazepam; Genopharm Brand of Temazepam; Normitab; Katwijk Brand of Temazepam; Nortem; Norton Brand of Temazepam; Novo-Temazepam; Novo Temazepam; Novopharm Brand of Temazepam; Nu-Temazepam; Nu Temazepam; Nu-Pharm Brand of Temazepam; Nu Pharm Brand of Temazepam; PMS-Temazepam; PMS Temazepam; Pharmascience Brand of Temazepam; Pronervon T; Scheffler Brand of Temazepam; Remestan; ICN Brand of Temazepam; Restoril; Novartis Brand of Temazepam; Mallinckrodt Brand of Temazepam; Ro-5-5345; Ro 5 5345; Ro55345; SaH 47-603; SaH 47 603; SaH 47603; Signopam; Temaze; Alphapharm Brand of Temazepam; temazep von ct; ct-Arzneimittel Brand of Temazepam; ct Arzneimittel Brand of Temazepam; Tenox; Orion Brand of Temazepam; WY-3917; WY 3917; WY3917; Apo-Temazepam; Apo Temazepam; Apotex Brand of Temazepam;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Hypnotics and Sedatives; Anti-Anxiety Agents; GABA Modulators;

Tree Number: D03.438.079.080.070.880;

History Note: 91(79); was see under BENZODIAZEPINE TRANQUILIZERS 1979-90