Testosterone
Research News and Information

Saturday, November 21, 2009

Normal spermatogenesis in a man with mutant luteinizing hormone.

3 Nov 2009 Men with mutations in LHB, the gene encoding the beta subunit of luteinizing hormone (LHB), have azoospermia with absent or few fetal Leydig cells. We report a mutation in LHB in a man and his sister. The man presented with absence of virilization, ... Read more...

Preliminary evaluation of the effect of dutasteride on PCA3 in post-DRE urine sediments: a randomized, open-label, parallel-group pilot study.

30 Oct 2009 BACKGROUND: Dutasteride is commonly used in patients that are also at risk for prostate cancer (PCa). Therefore, the influence of dutasteride on PCa markers has to be studied. To date, only the effect of dutasteride on serum prostate-specific ... Read more...

Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development.

7 Oct 2009 Common male reproductive abnormalities including cryptorchidism, hypospadias, and low sperm counts may comprise a testicular dysgenesis syndrome (TDS), resulting from fetal testis dysfunction during a critical developmental period involving reduced ... Read more...

Latest indexed articles for 'Testosterone'

These are the very latest articles for this heading:

• Normal spermatogenesis in a man with mutant luteinizing hormone. 3 Nov 2009
• Preliminary evaluation of the effect of dutasteride on PCA3 in post-DRE urine sediments: a randomized, open-label, parallel-group pilot study. 30 Oct 2009
• Degarelix (firmagon) for prostate cancer. 17 Oct 2009
• Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development. 7 Oct 2009
• Chronic exposure to anabolic androgenic steroids alters neuronal function in the mammalian forebrain via androgen receptor- and estrogen receptor-mediated mechanisms. 5 Oct 2009
• Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice. 29 Sep 2009
• Sex steroids are necessary in the second postnatal week for the expression of male alloparental behavior in prairie voles (Microtus ochragaster). 29 Sep 2009
• Prostate cancer: a newly discovered route for testosterone to reach the prostate : Treatment by super-selective intraprostatic androgen deprivation. 29 Sep 2009
• Hypogonadism-related symptoms: development and evaluation of an empirically derived self-rating instrument (HRS 'Hypogonadism Related Symptom Scale'). 29 Sep 2009
• Effects of primary testicular damage on sperm DNA oxidative status and embryonic and foetal development. 29 Sep 2009
• Predictors of improved seminal parameters and fertility after varicocele repair in young adults. 29 Sep 2009
• Editorial comment. 29 Sep 2009
• Effects of morphine on testosterone levels in rat C6 glioma cells: modulation by anastrozole. 29 Sep 2009
• Testosterone and unconscious positive priming increase human motivation separately. 21 Sep 2009
• Should testosterone replacement be given to men with large prostates? 14 Sep 2009
• Mechanisms of obesity and related pathologies: androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction. 13 Sep 2009
• Safety aspects of 36 months of administration of long-acting intramuscular testosterone undecanoate for treatment of female-to-male transgender individuals. 9 Sep 2009
• Sexual dimorphism and hormone responsiveness in the spinal cord of the socially monogamous prairie vole (Microtus ochrogaster). 8 Sep 2009
• Sex hormones and frailty in older men: the osteoporotic fractures in men (MrOS) study. 6 Sep 2009
• Effects of androgens on endothelial progenitor cells in vitro and in vivo. 5 Sep 2009

See a longer list of these articles.

Technical information about 'Testosterone'

Definition: A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.

Chemical name: Androst-4-en-17beta-ol-3-one

Registry Number: 58-22-0

Descriptor UI: D013739

Alternative terms: Testosterone; 17-beta-Hydroxy-4-Androsten-3-one; 17 beta Hydroxy 4 Androsten 3 one; Androtop; Dr. Kade Brand of Testosterone; Histerone; Hauck Brand of Testosterone; Sterotate; Ulmer Brand of Testosterone; Sustanon; Androderm; Watson Brand of Testosterone; Faulding Brand of Testosterone; Paladin Brand of Testosterone; AstraZeneca Brand of Testosterone; CEPA Brand of Testosterone; Testoderm; Ortho Brand of Testosterone; Ferring Brand of Testosterone; Testolin; Pasadena Brand of Testosterone; Testopel; Bartor Brand of Testosterone; Testosterone Sulfate; AndroGel; Solvay Brand of Testosterone; Unimed Brand of Testosterone; Schering Brand of Testosterone; 8-Isotestosterone; 8 Isotestosterone; 17-beta-Hydroxy-8 alpha-4-Androsten-3-one; 17 beta Hydroxy 8 alpha 4 Androsten 3 one; Andropatch; SmithKline Beecham Brand of Testosterone; GlaxoSmithKline Brand of Testosterone; Testim; Auxilium Pharmaceuticals Inc. Brand of Testosterone;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Androgens;

Tree Number: D04.808.054.079.429.824; D06.472.334.851.968.984;

History Note: 1963; for SUSTANON use TESTOSTERONE (NM) 1976-2003; /therapeutic use was TESTOSTERONE, THERAPEUTIC 1965

Technical Notes: TESTOSTERONE PROPIONATE is also available