Tetrahydrocannabinol - Pharmacology
Research News and Information

Sunday, November 22, 2009

Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis.

29 Sep 2009 Gliomas, one of the most malignant forms of cancer, exhibit high resistance to conventional therapies. Identification of the molecular mechanisms responsible for this resistance is therefore of great interest to improve the efficacy of the ... Read more...

Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood.

30 Jul 2009 Marijuana and hashish are the illicit drugs most frequently used by human adolescents. Given the continued neurodevelopment throughout adolescence, adolescents may be more vulnerable than adults to certain neural consequences of heavy marijuana use. ... Read more...

Effectiveness of a marijuana expectancy manipulation: Piloting the balanced-placebo design for marijuana.

30 Jul 2009 Although alcohol and nicotine administration studies have demonstrated that manipulating subjects' expectancies regarding drug content affects drug response, research with marijuana has not adequately studied drug expectancy effects. The present ... Read more...

Latest indexed articles for 'Tetrahydrocannabinol - Pharmacology'

These are the very latest articles for this heading:

• Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis. 29 Sep 2009
• Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood. 30 Jul 2009
• Effectiveness of a marijuana expectancy manipulation: Piloting the balanced-placebo design for marijuana. 30 Jul 2009
• Cannabinoid receptor ligands as potential anticancer agents--high hopes for new therapies? 29 Jun 2009
• Can recreational doses of THC produce significant dopamine release in the human striatum? 15 Jun 2009
• Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma. 7 Jun 2009
• Synthetic delta-9-tetrahydrocannabinol (dronabinol) can improve the symptoms of schizophrenia. 30 May 2009
• Discriminative stimulus properties of delta9-tetrahydrocannabinol (THC) in C57Bl/6J mice. 21 May 2009
• Cannabinoid 1 receptor activation inhibits transient receptor potential vanilloid type 1 receptor-mediated cationic influx into rat cultured primary sensory neurons. 18 May 2009
• Delta-9-tetrahydrocannabinol enhances food reinforcement in a mouse operant conflict test. 17 May 2009
• Comparison of subjective, pharmacokinetic, and physiological effects of marijuana smoked as joints and blunts. 12 May 2009
• Protracted cannabinoid administration elicits antidepressant behavioral responses in rats: role of gender and noradrenergic transmission. May 2009
• Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. 29 Apr 2009
• Cannabidiol reverses the reduction in social interaction produced by low dose Delta(9)-tetrahydrocannabinol in rats. 21 Apr 2009
• Actions of delta-9-tetrahydrocannabinol in cannabis: relation to use, abuse, dependence. 30 Mar 2009
• Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice. 30 Mar 2009
• Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the effects of Cannabis sativa on learning and psychosis. 30 Mar 2009
• Modulation of glycine receptor function by the synthetic cannabinoid HU210. 19 Mar 2009
• (Endo)cannabinoids mediate different Ca2+ entry mechanisms in human bronchial epithelial cells. Mar 2009
• Fungal biotransformation of cannabinoids: potential for new effective drugs. 27 Feb 2009

See a longer list of these articles.

Technical information about 'Tetrahydrocannabinol'

Definition: A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound. Dronabinol is a synthetic form of delta-9-THC.

Chemical name: 6H-Dibenzo(b,d)pyran-1-ol, 6a,7,8,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-

Registry Number: 1972-08-3

Descriptor UI: D013759

Alternative terms: Tetrahydrocannabinol; delta(1)-Tetrahydrocannabinol; THC; delta(9)-Tetrahydrocannabinol; delta(9)-THC; Dronabinol; 9-ene-Tetrahydrocannabinol; 9 ene Tetrahydrocannabinol; delta(1)-THC; Tetrahydrocannabinol, (6a-trans)-Isomer; Tetrahydrocannabinol, Trans-Isomer; Tetrahydrocannabinol, Trans Isomer; Tetrahydrocannabinol, (6aS-cis)-Isomer; Tetrahydrocannabinol, Trans-(+-)-Isomer; Marinol; Solvay Brand of Tetrahydrocannabinol; Tetrahydrocannabinol, (6aR-cis)-Isomer;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; biosynthesis;

Pharmacological Action: Hallucinogens; Psychotropic Drugs; Analgesics, Non-Narcotic;

Tree Number: D02.455.849.090.810;

History Note: 77(71); was see under CANNABIS 1975-76