Tetrahydronaphthalenes - Pharmacology
Research News and Information

Sunday, November 22, 2009

Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).

6 Oct 2009 This report describes the synthesis of analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (1), commonly known as bexarotene, and their analysis in acting as retinoid X receptor (RXR)-specific agonists. ... Read more...

Lack of pharmacokinetic interactions between transdermal rotigotine and oral levodopa/carbidopa.

21 Jul 2009 This open-label phase I trial assessed potential pharmacokinetic interactions between oral levodopa/carbidopa and transdermal rotigotine treatment at steady state. Twenty-four participants with idiopathic restless legs syndrome (12 per group) ... Read more...

Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction.

16 Jul 2009 Rotigotine is a novel, non-ergoline dopamine D(3)/D(2)/D(1)-receptor agonist for the treatment of Parkinson's disease that can be continuously delivered by the transdermal route to provide stable plasma levels. Continuous drug delivery should reduce ... Read more...

Latest indexed articles for 'Tetrahydronaphthalenes - Pharmacology'

These are the very latest articles for this heading:

• Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). 6 Oct 2009
• Lack of pharmacokinetic interactions between transdermal rotigotine and oral levodopa/carbidopa. 21 Jul 2009
• Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction. 16 Jul 2009
• Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver. 8 Jul 2009
• Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice. 29 Jun 2009
• Antidepressant effects of pramipexole, a dopamine D3/D2 receptor agonist, and 7-OH-DPAT, a dopamine D3 receptor agonist, in olfactory bulbectomized rats. 19 Jun 2009
• The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARbeta induction. 16 May 2009
• Bifeprunox and aripiprazole suppress in vivo VTA dopaminergic neuronal activity via D2 and not D3 dopamine autoreceptor activation. 16 May 2009
• Retinoic acid receptor stimulation protects midbrain dopaminergic neurons from inflammatory degeneration via BDNF-mediated signaling. 13 May 2009
• (1R, 3S)-(-)-trans-PAT: a novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity. May 2009
• Placental steroidogenesis in rats is independent of signaling pathways induced by retinoic acids. May 2009
• Discovery of tetrahydrotetramethylnaphthalene analogs as adult T-cell leukemia cell-selective proliferation inhibitors in a small chemical library constructed based on multi-template hypothesis. May 2009
• [Potentiation of nitric oxide-dependent activation of soluble guanylate cyclase by levomycetin, tetracycline, and oxolin] 29 Apr 2009
• Synthesis and anticancer activity of novel tetralin-6-ylpyridine and tetralin-6-ylpyrimidine derivatives. 29 Apr 2009
• Synthesis of novel tetrahydronaphthalen-2-yl heterocycles for analgesic, anti-inflammatory and antipyretic evaluation. 29 Apr 2009
• Synthetic retinoid AM80 inhibits Th17 cells and ameliorates experimental autoimmune encephalomyelitis. 21 Apr 2009
• Investigation of various N-heterocyclic substituted piperazine versions of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol: effect on affinity and selectivity for dopamine D3 receptor. 17 Apr 2009
• Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities. 13 Apr 2009
• Design, synthesis, and biological evaluation of novel diarylalkyl amides as TRPV1 antagonists. 9 Apr 2009
• Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel. 6 Apr 2009

See a longer list of these articles.

Technical information about 'Tetrahydronaphthalenes'

Definition: Partially saturated 1,2,3,4-tetrahydronaphthalene compounds.

Registry Number: 0

Descriptor UI: D013764

Alternative terms: Tetrahydronaphthalenes; Tetralins;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.455.426.559.847.638.960; D04.615.638.960;

History Note: 91(78); was see under NAPHTHALENES 1978-90