Tetrahydronaphthalenes
Research News and Information

Monday, November 23, 2009

Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene).

6 Oct 2009 This report describes the synthesis of analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (1), commonly known as bexarotene, and their analysis in acting as retinoid X receptor (RXR)-specific agonists. ... Read more...

Lasofoxifene, a new selective estrogen receptor modulator for the treatment of osteoporosis and vaginal atrophy.

30 Aug 2009 Selective estrogen receptor modulators (SERMs) represent a class with a growing number of compounds that act as either estrogen receptor (ER) agonists or antagonists in a tissue-specific manner. The purpose of this article is to review the effects ... Read more...

Functional primary amines and diamines from alpha-aminoacids. a concise route to substituted 2-aminotetralins.

18 Aug 2009 S-Phthalimidomethyl xanthates derived from various alpha-amino acids add efficiently to a range of unactivated alkenes to give a variety of highly functionalized, protected amines. In the case of phenylalanine and tyrosine derived xanthates, the ... Read more...

Latest indexed articles for 'Tetrahydronaphthalenes'

These are the very latest articles for this heading:

• Modeling, synthesis and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene). 6 Oct 2009
• Lasofoxifene, a new selective estrogen receptor modulator for the treatment of osteoporosis and vaginal atrophy. 30 Aug 2009
• Functional primary amines and diamines from alpha-aminoacids. a concise route to substituted 2-aminotetralins. 18 Aug 2009
• Phase I/II randomized bilateral half-head comparison of topical bexarotene 1% gel for alopecia areata. 12 Aug 2009
• Co-ordinated regulation of two divergent promoters through higher-order complex formation by the LysR-type regulator ThnR. 2 Aug 2009
• Systemic progression following complete cutaneous remission under bexarotene treatment for tumor-stage mycosis fungoides. 30 Jul 2009
• Lack of pharmacokinetic interactions between transdermal rotigotine and oral levodopa/carbidopa. 21 Jul 2009
• Continuous administration of rotigotine to MPTP-treated common marmosets enhances anti-parkinsonian activity and reduces dyskinesia induction. 16 Jul 2009
• Rexinoid bexarotene modulates triglyceride but not cholesterol metabolism via gene-specific permissivity of the RXR/LXR heterodimer in the liver. 8 Jul 2009
• Aliphatic C-H bond activation initiated by a (mu-eta2:eta2-peroxo)dicopper(II) complex in comparison with cumylperoxyl radical. 6 Jul 2009
• Occurrence of brominated flame retardants, polycyclic musks, and chlorinated naphthalenes in seal blubber from Antarctica: comparison to organochlorines. 2 Jul 2009
• High doses of rotigotine transdermal patch: results of an open-label, dose-escalation trial in patients with advanced-stage, idiopathic Parkinson disease. 29 Jun 2009
• Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice. 29 Jun 2009
• Antidepressant effects of pramipexole, a dopamine D3/D2 receptor agonist, and 7-OH-DPAT, a dopamine D3 receptor agonist, in olfactory bulbectomized rats. 19 Jun 2009
• Chemical composition of the essential oils of the flowers, leaves and stems of two senecio polyanthemoides Sch. Bip. samples from South Africa. 7 Jun 2009
• Synergistic interactions between the synthetic retinoid tamibarotene and glucocorticoids in human myeloma cells. 30 May 2009
• The ATRA-dependent overexpression of the glutamate transporter EAAC1 requires RARbeta induction. 16 May 2009
• Bifeprunox and aripiprazole suppress in vivo VTA dopaminergic neuronal activity via D2 and not D3 dopamine autoreceptor activation. 16 May 2009
• [Distribution character of synthetic musks in urban sewage sludges] 13 May 2009
• Pramipexole induced compulsive behaviors abate after initiation of rotigitine. 13 May 2009

See a longer list of these articles.

Technical information about 'Tetrahydronaphthalenes'

Definition: Partially saturated 1,2,3,4-tetrahydronaphthalene compounds.

Registry Number: 0

Descriptor UI: D013764

Alternative terms: Tetrahydronaphthalenes; Tetralins;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.455.426.559.847.638.960; D04.615.638.960;

History Note: 91(78); was see under NAPHTHALENES 1978-90