Tetrodotoxin
Research News and Information

Sunday, November 22, 2009

Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking.

27 Oct 2009 Modification of NMDA receptor function and trafficking contributes to the regulation of synaptic transmission and is important for several forms of synaptic plasticity. Here, we report that NMDA receptor subunits NR2A and NR2B have two distinct ... Read more...

Nitric oxide potentiation of locomotor activity in the spinal cord of the lamprey.

19 Oct 2009 To understand the intrinsic operation of spinal networks generating locomotion, we need to not only characterize the constituent neurons and their connectivity, but also determine the role of intrinsic modulation in shaping the final motor output. ... Read more...

Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord.

19 Oct 2009 Coactivation of spinal alpha(2)-adrenergic receptors (ARs) and opioid receptors produces antinociceptive synergy. Antinociceptive synergy between intrathecally administered alpha(2)AR and opioid agonists is well documented, but the mechanism ... Read more...

Latest indexed articles for 'Tetrodotoxin'

These are the very latest articles for this heading:

• Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking. 27 Oct 2009
• Nitric oxide potentiation of locomotor activity in the spinal cord of the lamprey. 19 Oct 2009
• Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord. 19 Oct 2009
• Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities. 19 Oct 2009
• Functional recovery after lesion of a central pattern generator. 19 Oct 2009
• Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity. 12 Oct 2009
• Differential involvement of beta3 integrin in pre- and postsynaptic forms of adaptation to chronic activity deprivation. 14 Sep 2009
• GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses. 14 Sep 2009
• Negative shift in the glycine reversal potential mediated by a Ca2+- and pH-dependent mechanism in interneurons. 14 Sep 2009
• Ranolazine as a cardioplegia additive improves recovery of diastolic function in isolated rat hearts. 13 Sep 2009
• Developmental switch of the expression of ion channels in human dendritic cells. 9 Sep 2009
• Visualizing sodium dynamics in isolated cardiomyocytes using fluorescent nanosensors. Sep 2009
• Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8. 30 Aug 2009
• Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy. 29 Aug 2009
• Dorsal hippocampal regulation of memory reconsolidation processes that facilitate drug context-induced cocaine-seeking behavior in rats. 25 Aug 2009
• Protection of neurons derived from human neural progenitor cells by veratridine. 24 Aug 2009
• Otoferlin is critical for a highly sensitive and linear calcium-dependent exocytosis at vestibular hair cell ribbon synapses. 24 Aug 2009
• A slowly inactivating sodium current contributes to spontaneous diastolic depolarization of atrial myocytes. 19 Aug 2009
• Spikes and membrane potential oscillations in hair cells generate periodic afferent activity in the frog sacculus. 10 Aug 2009
• Lidocaine, tetrodotoxin and their effect on consolidation of spatial memory. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Tetrodotoxin'

Definition: An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.

Registry Number: 4368-28-9

Descriptor UI: D013779

Alternative terms: Tetrodotoxin; Tetradotoxin; Fugu Toxin; Toxin, Fugu; Tarichatoxin;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Poisons; Sodium Channel Blockers; Anesthetics, Local;

Tree Number: D03.438.786.910; D23.946.580.910;

History Note: 68(64)

Technical Notes: /antag permitted but consider also ANTITOXINS