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Thiazoles
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Sunday, November 22, 2009

Activity of tyrosine kinase inhibitor Dasatinib in neuroblastoma cells in vitro and in orthotopic mouse model.

29 Nov 2009 Stage 4 neuroblastoma (NB) is a devastating childhood cancer whose poor outcome has remained essentially unchanged in the last 20 years. Receptor tyrosine kinases have important roles in the control of proliferation, differentiation and apoptosis of ... Read more...


Flow cytometric determination of Src phosphorylation in pediatric patients treated with dasatinib.

29 Nov 2009 Tyrosine kinase inhibitors, such as imatinib, have dramatically improved the outcomes for patients with selected cancers. For imatinib, western blotting of phospho-CrkL was an insensitive, indirect, and descriptive method to determine drug efficacy. ... Read more...


Radiosensitization effect of STI-571 on pancreatic cancer cells in vitro.

30 Oct 2009 PURPOSE: To examine STI-571-induced radiosensitivity in human pancreatic cancer cells in vitro. METHODS AND MATERIALS: Three human pancreatic cancer cell lines (Bxpc-3, Capan-1, and MiaPaCa-2) exhibiting different expression levels of c-Kit and ... Read more...

 

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Technical information about 'Thiazoles'

Registry Number: 0

Descriptor UI: D013844

Alternative terms: Thiazoles;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.886.675; D03.383.129.708;

Technical Notes: includes thiazolines, thiazolidines

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