Thiopental
Research News and Information

Sunday, November 22, 2009

Effects of thiopental on endothelium-dependent relaxation in porcine coronary arteries.

29 Jun 2009 This study investigated the effects of thiopental on endothelium-dependent relaxation (EDR), and especially the effects on nitric oxide- and prostacyclin-independent EDR. Fresh porcine coronary artery rings (4 mm long), were consecutively tested ... Read more...

Total synthesis of brevenal.

16 Jun 2009 A total synthesis of brevenal is described. The pentacyclic ether core was constructed by the intramolecular allylation of alpha-acetoxy ether and subsequent ring-closing metathesis. Both of the diene side chains were introduced by Wittig ... Read more...

The k-in-a-row up-and-down design, revisited.

13 Jun 2009 The percentile-finding experimental design known variously as 'forced-choice fixed-staircase', 'geometric up-and-down' or 'k-in-a-row' (KR) was introduced by Wetherill four decades ago. To date, KR has been by far the most widely used up-and-down ... Read more...

Latest indexed articles for 'Thiopental'

These are the very latest articles for this heading:

• Four years of successful maintenance electroconvulsive therapy. 30 Aug 2009
• Effects of thiopental on endothelium-dependent relaxation in porcine coronary arteries. 29 Jun 2009
• Total synthesis of brevenal. 16 Jun 2009
• The k-in-a-row up-and-down design, revisited. 13 Jun 2009
• Association of vaginal bleeding and electroconvulsive therapy use in pregnancy. 30 May 2009
• Comparison of propofol and thiopental as anesthetic agents for electroconvulsive therapy: a randomized, blinded comparison of seizure duration, stimulus charge, clinical effect, and cognitive side effects. 30 May 2009
• Rapid sequence induction in obstetrics revisited. 30 May 2009
• Polymyoclonus seizure resulting from accidental injection of tranexamic acid in spinal anesthesia. 30 May 2009
• Hypokalaemia with severe rebound hyperkalaemia after therapeutic barbiturate coma. 30 May 2009
• The preparation and storage of anaesthetic drugs for obstetric emergencies: a survey of UK practice. 20 May 2009
• Thiopental inhibits lipopolysaccharide-induced tissue factor expression. 11 May 2009
• Effect of endogenous progesterone and oestradiol-17beta on the incidence of gastro-oesophageal reflux and on the barrier pressure during general anaesthesia in the female dog. 10 May 2009
• Effects of remifentanil on cardiovascular and bispectral index responses to endotracheal intubation in severe pre-eclamptic patients undergoing Caesarean delivery under general anaesthesia. 6 May 2009
• The effect of postoperative fasting on vomiting in children and their assessment of pain. 29 Apr 2009
• Alternative anesthetic management of a child with spastic quadriplegia due to metachromatic leukodystrophy using total intravenous anesthesia. 29 Apr 2009
• A lateral percutaneous technique for stellate ganglion blockade in rats. 29 Apr 2009
• Comparison of the effects of three different combinations of general anesthetics on the electroretinogram of dogs. 12 Apr 2009
• A critical review: does thiopental continuous infusion warrant therapeutic drug monitoring in the critical care population? 30 Mar 2009
• The effect of thiopentone on severity and duration of succinylcholine-induced fasciculation. 27 Feb 2009
• Thiamylal and thiopental attenuate beta-adrenergic signaling pathway by suppressing adenylyl cyclase in rat ventricular myocytes. 27 Feb 2009

See a longer list of these articles.

Technical information about 'Thiopental'

Definition: A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not produce any excitation but has poor analgesic and muscle relaxant properties. Small doses have been shown to be anti-analgesic and lower the pain threshold. (From Martindale, The Extra Pharmacopoeia, 30th ed, p920)

Chemical name: 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-

Registry Number: 76-75-5

Descriptor UI: D013874

Alternative terms: Thiopental; Thiomebumal; Pharmtech Brand of Thiopental Sodium; Thiopentone; Bomathal; Penthiobarbital; Thiopentobarbital; Pentothal; Pentothal Sodico; Merial Brand of Thiopental Sodium; Abbott Brand of Thiopental Sodium; Sodipental; Pisa Brand of Thiopental Sodium; Trapanal; Altana Pharma Brand of Thiopental Sodium; Thiopental Nycomed; Nycomed Brand of Thiopental Sodium; Thiopental Sodium; Tiobarbital Braun; Braun Brand of Thiopental Sodium; Nesdonal; Rhone Merieux Brand of Thiopental Sodium; Thionembutal;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Hypnotics and Sedatives; Anesthetics, Intravenous; GABA Modulators; Anticonvulsants;

Tree Number: D03.383.742.698.253.800.810;