Thymine - Chemistry
Research News and Information

Monday, November 23, 2009

The cis-(5R,6S)-thymine glycol lesion occupies the wobble position when mismatched with deoxyguanosine in DNA.

18 Oct 2009 Oxidative damage to 5-methylcytosine in DNA, followed by deamination, yields thymine glycol (Tg), 5,6-dihydroxy-5,6-dihydrothymine, mispaired with deoxyguanosine. The structure of the 5R Tg.G mismatch pair has been refined using a combination of ... Read more...

Interactions of the "piano-stool" [ruthenium(II) (eta6-arene)(en)CL]+ complexes with water and nucleobases; ab initio and DFT study.

30 Aug 2009 Piano stool ruthenium complexes of the composition [Ru(II)(eta6-arene)(en)Cl](+/2+) (en = ethylenediamine) represent an emerging class of cisplatin-analogue anticancer drug candidates. In this study, we use computational quantum chemistry to ... Read more...

Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB.

9 Aug 2009 Promiscuous substrate recognition, the ability to catalyze transformations of chemically diverse compounds, is an evolutionarily advantageous, but poorly understood phenomenon. The promiscuity of DNA repair enzymes is particularly important, because ... Read more...

Latest indexed articles for 'Thymine - Chemistry'

These are the very latest articles for this heading:

• The cis-(5R,6S)-thymine glycol lesion occupies the wobble position when mismatched with deoxyguanosine in DNA. 18 Oct 2009
• Interactions of the "piano-stool" [ruthenium(II) (eta6-arene)(en)CL]+ complexes with water and nucleobases; ab initio and DFT study. 30 Aug 2009
• Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB. 9 Aug 2009
• Fingerprints of bonding motifs in DNA duplexes of adenine and thymine revealed from circular dichroism: synchrotron radiation experiments and TDDFT calculations. 14 Jul 2009
• Effects of hydration on the proton transfer mechanism in the adenine-thymine base pair. 7 Jul 2009
• Quantitative structure-activity relationship study on the anti-HIV-1 activity of novel 6-naphthylthio HEPT analogs. 20 Jun 2009
• Hydrogen bonding between adenine-modified surfaces and terminal thymine-functionalized polystyrene: influence of the surface adenine concentration on polymer recognition. 14 Jun 2009
• Processing of thymine glycol in a clustered DNA damage site: mutagenic or cytotoxic. 23 May 2009
• Highly sensitive fluorescent sensor for mercury ion based on photoinduced charge transfer between fluorophore and pi-stacked T-Hg(II)-T base pairs. 10 May 2009
• Desorption electrospray ionization mass spectrometry of DNA nucleobases: implications for a liquid film model. 29 Apr 2009
• Conformationally controlled, thymine-based alpha-nucleopeptides. 28 Apr 2009
• Thymine dimerization in DNA model systems: cyclobutane photolesion is predominantly formed via the singlet channel. 13 Apr 2009
• Dramatic effect of single-base mutation on the conformational dynamics of human telomeric G-quadruplex. 7 Apr 2009
• Quintets of uracil and thymine: a novel structure of nucleobase self-assembly studied by electrospray ionization mass spectrometry. 28 Mar 2009
• Parallel RNA-strand recognition by 2'-amino-beta-L-LNA. 22 Mar 2009
• A density functional theory (DFT) study on gas-phase proton transfer reactions of derivatized and underivatized peptide ions generated by matrix-assisted laser desorption ionization. 18 Mar 2009
• Photoinduced nonadiabatic dynamics of pyrimidine nucleobases: on-the-fly surface-hopping study with semiempirical methods. 17 Mar 2009
• Thymine relaxation after UV irradiation: the role of tautomerization and pi-sigma* states. 11 Mar 2009
• Nature of bonding in nine planar hydrogen-bonded adenine...thymine base pairs. 3 Mar 2009
• Synthesis and characterisation of hetero-bimetallic organometallic phenylalanine and PNA monomer derivatives. 7 Feb 2009

See a longer list of these articles.

Technical information about 'Thymine'

Chemical name: 2,4(1H,3H)-Pyrimidinedione, 5-methyl-

Registry Number: 65-71-4

Descriptor UI: D013941

Alternative terms: Thymine; 5-Methyluracil; 5 Methyluracil;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; biosynthesis; physiology;

Tree Number: D03.383.742.698.875.899;

Technical Notes: /biosyn /physiol permitted; thymine deoxyriboside, thymine deoxyribonucleoside = THYMIDINE