Thyroxine - Metabolism
Research News and Information

Thursday, March 18, 2010

Type 1 deiodinase activity and generation of triiodothyronine (T3) in prostate of sexually active rats.

30 Oct 2009 BACKGROUND: Thyroxine (T(4)) and triiodothyronine (T(3)) are involved in the development and function of the male reproductive system. The type 1 deiodinase enzyme (D1) plays a major role in the intracellular conversion of T(4) to the active form, ... Read more...

The blood-brain barrier thyroxine transporter organic anion-transporting polypeptide 1c1 displays atypical transport kinetics.

7 Oct 2009 Organic anion-transporting polypeptide (Oatp) 1c1 is a high-affinity T(4) transporter expressed in brain barrier cells. Oatp1c1 transports a variety of additional ligands including the conjugated sterol estradiol 17beta-glucuronide (E(2)17betaG). ... Read more...

Synergistic acceleration of thyroid hormone degradation by phenobarbital and the PPAR alpha agonist WY14643 in rat hepatocytes.

20 Jul 2009 Energy balance is maintained by controlling both energy intake and energy expenditure. Thyroid hormones play a crucial role in regulating energy expenditure. Their levels are adjusted by a tight feedback-controlled regulation of thyroid hormone ... Read more...

Latest indexed articles for 'Thyroxine - Metabolism'

These are the very latest articles for this heading:

• Type 1 deiodinase activity and generation of triiodothyronine (T3) in prostate of sexually active rats. 30 Oct 2009
• The blood-brain barrier thyroxine transporter organic anion-transporting polypeptide 1c1 displays atypical transport kinetics. 7 Oct 2009
• Synergistic acceleration of thyroid hormone degradation by phenobarbital and the PPAR alpha agonist WY14643 in rat hepatocytes. 20 Jul 2009
• Estradiol-17beta and linseed meal interact to alter visceral organ mass and hormone concentrations from ovariectomized ewes. 15 Jun 2009
• Cardiac sarcoplasmic reticulum Ca2+-ATPase: heat production and phospholamban alterations promoted by cold exposure and thyroid hormone. 10 Jun 2009
• Molecular cloning, expression and characterization of a novel mouse SULT6 cytosolic sulfotransferase. 6 Jun 2009
• A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport. 2 Jun 2009
• Biases in antibody-based single-phase assays for free thyroxine due to protein-bound analyte. Jun 2009
• Effects of energy restriction on thyroid hormone metabolism in chickens. 30 May 2009
• Predictors of time to remission and treatment failure in patients with Graves' disease treated with propylthiouracil. 30 May 2009
• Triumphs of the thyroid despite lesser conversion. 30 May 2009
• Anti-thyroid hormone activity of bisphenol A, tetrabromobisphenol A and tetrachlorobisphenol A in an improved reporter gene assay. 16 May 2009
• Iodothyronine deiodinases and thyroid hormone receptors regulation during flatfish (Solea senegalensis) metamorphosis. 13 May 2009
• Gas-phase unfolding and disassembly reveals stability differences in ligand-bound multiprotein complexes. 22 Apr 2009
• Thyroid histopathology assessments for the amphibian metamorphosis assay to detect thyroid-active substances. 20 Apr 2009
• Substrate specificity of transthyretin: identification of natural substrates in the nervous system. 13 Apr 2009
• Glycosyltransferase function in core 2-type protein O glycosylation. 4 Apr 2009
• Novel insights into thyroid hormones from the study of common genetic variation. 30 Mar 2009
• Thyroid disruption by low-dose BDE-47 in prenatally exposed lambs. 22 Mar 2009
• Nongenomic actions of L-thyroxine and 3,5,3'-triiodo-L-thyronine. Focus on "L-Thyroxine vs. 3,5,3'-triiodo-L-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase". 16 Mar 2009

See a longer list of these articles.

Technical information about 'Thyroxine'

Definition: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.

Chemical name: Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-

Registry Number: 7488-70-2

Descriptor UI: D013974

Alternative terms: Thyroxine; L-3,5,3',5'-Tetraiodothyronine; L-Thyroxine; L Thyroxine; Thyroxin; O-(4-Hydroxy-3,5-diiodophenyl) 3,5-diiodo-L-tyrosine; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine; T4 Thyroid Hormone; Thyroid Hormone, T4; 3,5,3',5'-Tetraiodothyronine; Levothyroxine; Levothroid; Aventis Brand of Levothyroxine Sodium; Forest Brand of Levothyroxine Sodium; Levothyroxine Sodium; Sodium Levothyroxine; Levoxine; Levoxyl; Monarch Brand of Levothyroxine Sodium; Lévothyrox; Merck Lipha Santé Brand of Levothyroxine Sodium; Novothyral; Novothyrox; Genpharm Brand of Levothyroxine Sodium; Oroxine; Sigma Brand of Levothyroxine Sodium; Synthroid; Abbot Brand of Levothyroxine Sodium; Synthrox; Vortex Brand of Levothyroxine Sodium; Thyrax; Nourypharma Brand of Levothyroxine Sodium; Tiroidine; Rudefsa Brand of Levothyroxine Sodium; Tiroxina Leo; Leo, Tiroxina; Byk Brand of Levothyroxine Sodium; Unithroid; Watson Brand of Levothyroxine Sodium; Berlthyrox; Berlin-Chemie Brand of Levothyroxine Sodium; Berlin Chemie Brand of Levothyroxine Sodium; Dexnon; Kern Brand of Levothyroxine Sodium; Eferox; Hexal Brand 1 of Levothyroxine Sodium; Eltroxin; GlaxoSmithKline Brand of Levothyroxine Sodium; Goldshield Brand of Levothyroxine Sodium; Thevier; Allphar Brand of Levothyroxine Sodium; GlaxoWellcome Brand of Levothyroxine Sodium; Eltroxine; Euthyrox; Merck Brand of Levothyroxine Sodium; Eutirox; L-Thyrox; L Thyrox; Hexal Brand 2 of Levothyroxine Sodium; L-Thyroxin beta; L Thyroxin beta; LThyroxin beta; betapharm Brand of Levothyroxine Sodium; L-Thyroxin Henning; L Thyroxin Henning; LThyroxin Henning; Sanofi Synthelabo Brand of Levothyroxine Sodium; Henning Berlin Brand of Levothyroxine Sodium; L-Thyroxine Roche; L Thyroxine Roche; Roche Brand of Levothyroxine Sodium; Levo-T; Levo T; LevoT; Mova Brand of Levothyroxine Sodium; Levothyroid; Levothyroxin Deladande; Deladande, Levothyroxin; Levothyroxin Delalande; Delalande, Levothyroxin; Delalande Brand of Levothyroxine Sodium;

Related Mesh Headings: Hyperthyroxinemia; Receptors, Thyroid Hormone;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D06.472.931.812; D12.125.072.050.767;

History Note: 1965; use THYROXIN 1963-1964; for LEVOTHYROXINE use LEVOTHYROXINE 1991-2001, use THYROXINE 1966-1990

Technical Notes: /blood: consider also HYPERTHYROXINEMIA