Thyroxine
Research News and Information

Saturday, November 21, 2009

Type 1 deiodinase activity and generation of triiodothyronine (T3) in prostate of sexually active rats.

30 Oct 2009 BACKGROUND: Thyroxine (T(4)) and triiodothyronine (T(3)) are involved in the development and function of the male reproductive system. The type 1 deiodinase enzyme (D1) plays a major role in the intracellular conversion of T(4) to the active form, ... Read more...

The influence of thyroid hormones on periodontitis-related bone loss and tooth-supporting alveolar bone: a histological study in rats.

20 Oct 2009 BACKGROUND AND OBJECTIVE: Recent studies have pointed to potentially periodontal risk indicators, however no information is available on the impact of changes in thyroid hormone levels on the progression of periodontitis and on the quality of ... Read more...

The blood-brain barrier thyroxine transporter organic anion-transporting polypeptide 1c1 displays atypical transport kinetics.

7 Oct 2009 Organic anion-transporting polypeptide (Oatp) 1c1 is a high-affinity T(4) transporter expressed in brain barrier cells. Oatp1c1 transports a variety of additional ligands including the conjugated sterol estradiol 17beta-glucuronide (E(2)17betaG). ... Read more...

Latest indexed articles for 'Thyroxine'

These are the very latest articles for this heading:

• Type 1 deiodinase activity and generation of triiodothyronine (T3) in prostate of sexually active rats. 30 Oct 2009
• The influence of thyroid hormones on periodontitis-related bone loss and tooth-supporting alveolar bone: a histological study in rats. 20 Oct 2009
• Generic drugs revisited. 17 Oct 2009
• The blood-brain barrier thyroxine transporter organic anion-transporting polypeptide 1c1 displays atypical transport kinetics. 7 Oct 2009
• Thyroid hormones induce cell proliferation and survival in ovarian granulosa cells COV434. 29 Sep 2009
• Phenytoin toxicity and thyroid dysfunction. 23 Sep 2009
• Novel ABCB11 mutations in a Thai infant with progressive familial intrahepatic cholestasis. 12 Sep 2009
• Regular aerobic exercise training improves endothelium-dependent arterial dilation in patients with subclinical hypothyroidism. 6 Sep 2009
• Experience with intraamniotic thyroxine treatment in nonimmune fetal goitrous hypothyroidism in 12 cases. 6 Sep 2009
• Thyroid hormone therapy for obesity and nonthyroidal illnesses: a systematic review. 6 Sep 2009
• Soluble CTLA-4 receptor an immunological marker of Graves' disease and severity of ophthalmopathy is associated with CTLA-4 Jo31 and CT60 gene polymorphisms. 2 Sep 2009
• Validation and application of an immunofluorimetric assay for detection of serum free triiodothyronine and free thyroxine concentrations in buffalo (Bubalus bubalis) under various physiological conditions. 30 Aug 2009
• Response to Heijboer et al. Ann Clin Biochem 2009;46(3):263-4. 30 Aug 2009
• Autoimmune thyroid disease and autoimmune rheumatic disorders: a two-sided analysis. 30 Aug 2009
• Elevated free thyroxine levels detected by a neonatal screening system. 30 Aug 2009
• Thyroid function: the complexity of maternal hypothyroidism during pregnancy. 30 Aug 2009
• Thyroid function: Thyroid hormones, iodine and the brain-an important concern. 30 Aug 2009
• [Dried porcine thyroid gland contra levothyroxine (Levaxin) in hypothyroidism] 30 Aug 2009
• Acclimation to heat during incubation: 4. Blood hormones and metabolites in broilers exposed to daily high temperatures. 30 Aug 2009
• Free thyroxine is an independent predictor of subcutaneous fat in euthyroid individuals. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Thyroxine'

Definition: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.

Chemical name: Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-

Registry Number: 7488-70-2

Descriptor UI: D013974

Alternative terms: Thyroxine; L-3,5,3',5'-Tetraiodothyronine; L-Thyroxine; L Thyroxine; Thyroxin; O-(4-Hydroxy-3,5-diiodophenyl) 3,5-diiodo-L-tyrosine; O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine; T4 Thyroid Hormone; Thyroid Hormone, T4; 3,5,3',5'-Tetraiodothyronine; Levothyroxine; Levothroid; Aventis Brand of Levothyroxine Sodium; Forest Brand of Levothyroxine Sodium; Levothyroxine Sodium; Sodium Levothyroxine; Levoxine; Levoxyl; Monarch Brand of Levothyroxine Sodium; Lévothyrox; Merck Lipha Santé Brand of Levothyroxine Sodium; Novothyral; Novothyrox; Genpharm Brand of Levothyroxine Sodium; Oroxine; Sigma Brand of Levothyroxine Sodium; Synthroid; Abbot Brand of Levothyroxine Sodium; Synthrox; Vortex Brand of Levothyroxine Sodium; Thyrax; Nourypharma Brand of Levothyroxine Sodium; Tiroidine; Rudefsa Brand of Levothyroxine Sodium; Tiroxina Leo; Leo, Tiroxina; Byk Brand of Levothyroxine Sodium; Unithroid; Watson Brand of Levothyroxine Sodium; Berlthyrox; Berlin-Chemie Brand of Levothyroxine Sodium; Berlin Chemie Brand of Levothyroxine Sodium; Dexnon; Kern Brand of Levothyroxine Sodium; Eferox; Hexal Brand 1 of Levothyroxine Sodium; Eltroxin; GlaxoSmithKline Brand of Levothyroxine Sodium; Goldshield Brand of Levothyroxine Sodium; Thevier; Allphar Brand of Levothyroxine Sodium; GlaxoWellcome Brand of Levothyroxine Sodium; Eltroxine; Euthyrox; Merck Brand of Levothyroxine Sodium; Eutirox; L-Thyrox; L Thyrox; Hexal Brand 2 of Levothyroxine Sodium; L-Thyroxin beta; L Thyroxin beta; LThyroxin beta; betapharm Brand of Levothyroxine Sodium; L-Thyroxin Henning; L Thyroxin Henning; LThyroxin Henning; Sanofi Synthelabo Brand of Levothyroxine Sodium; Henning Berlin Brand of Levothyroxine Sodium; L-Thyroxine Roche; L Thyroxine Roche; Roche Brand of Levothyroxine Sodium; Levo-T; Levo T; LevoT; Mova Brand of Levothyroxine Sodium; Levothyroid; Levothyroxin Deladande; Deladande, Levothyroxin; Levothyroxin Delalande; Delalande, Levothyroxin; Delalande Brand of Levothyroxine Sodium;

Related Mesh Headings: Hyperthyroxinemia; Receptors, Thyroid Hormone;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D06.472.931.812; D12.125.072.050.767;

History Note: 1965; use THYROXIN 1963-1964; for LEVOTHYROXINE use LEVOTHYROXINE 1991-2001, use THYROXINE 1966-1990

Technical Notes: /blood: consider also HYPERTHYROXINEMIA