Tissue Inhibitor of Metalloproteinase-1 - Biosynthesis
Research News and Information

Sunday, November 22, 2009

IL-10 is a negative regulatory factor of CAWS-vasculitis in CBA/J mice as assessed by comparison with Bruton's tyrosine kinase-deficient CBA/N mice.

10 Aug 2009 Candida albicans water-soluble fraction (CAWS), a mannoprotein-beta-glucan complex obtained from the culture supernatant of C. albicans NBRC1385, exhibits vasculitis-inducing activity (CAWS-vasculitis) in mice. The sensitivity to CAWS-vasculitis ... Read more...

Expression of IL-1beta, MMP-9 and TIMP-1 on the pressure side of gingiva under orthodontic loading.

29 Jun 2009 OBJECTIVES: To test the hypothesis that orthodontic pressure does not induce gene transcription of IL-1beta, MMP-9, and TIMP-1 in pressure gingival soft tissue. MATERIALS AND METHODS: A total of 14 male Wistar rats were used with three rats as no ... Read more...

Suberoylanilide hydroxamic acid: a potential epigenetic therapeutic agent for lung fibrosis?

29 Jun 2009 Pulmonary fibrosis represents a fatal stage of interstitial lung diseases of known and idiopathic aetiology. No effective therapy is currently available. Based on an indication-discovery approach we present novel in vitro evidence that the histone ... Read more...

Latest indexed articles for 'Tissue Inhibitor of Metalloproteinase-1 - Biosynthesis'

These are the very latest articles for this heading:

• IL-10 is a negative regulatory factor of CAWS-vasculitis in CBA/J mice as assessed by comparison with Bruton's tyrosine kinase-deficient CBA/N mice. 10 Aug 2009
• Expression of IL-1beta, MMP-9 and TIMP-1 on the pressure side of gingiva under orthodontic loading. 29 Jun 2009
• Suberoylanilide hydroxamic acid: a potential epigenetic therapeutic agent for lung fibrosis? 29 Jun 2009
• Platelet-derived growth factor and transforming growth factor-beta modulate the expression of matrix metalloproteinases and migratory function of human airway smooth muscle cells. 9 Jun 2009
• Thrombin regulates matrix metalloproteinase-9 expression in human monocytes. 16 May 2009
• Th1-type epitopes-based cocktail PDDV attenuates hepatic fibrosis in C57BL/6 mice with chronic Schistosoma japonicum infection. 13 May 2009
• Effect of praziquantel treatment on the expression of matrix metalloproteinases in relation to tissue resorption during fibrosis in hamsters with acute and chronic Opisthorchis viverrini infection. 5 May 2009
• Effect of all-trans retinoic acid on renal expressions of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rats with glomerulosclerosis. 7 Apr 2009
• Effects of low concentrations of benzene on human lung cells in vitro. 29 Mar 2009
• Endogenous hydrogen sulfide regulates pulmonary artery collagen remodeling in rats with high pulmonary blood flow. 18 Feb 2009
• Correlation between MMPs and their inhibitors in breast cancer tumor tissue specimens and in cell lines with different metastatic potential. 12 Jan 2009
• Abnormal expression of MMP-9 and imbalance of MMP-9/TIMP-1 is associated with prolonged uterine bleeding after a medical abortion with mifepristone and misoprostol. 30 Dec 2008
• Continuos intravenous infusion of atrial natriuretic peptide (ANP) prevented liver fibrosis in rat. 4 Nov 2008
• MMP-2 expression precedes the final ripening process of the bovine cervix. 30 Oct 2008
• Plasminogen activator inhibitor-2, but not cystatin C, inhibits the prometastatic activity of tissue inhibitor of metalloproteinases-1 in the liver. 29 Sep 2008
• TIMP-1 overexpression promotes tumorigenesis of MDA-MB-231 breast cancer cells and alters expression of a subset of cancer promoting genes in vivo distinct from those observed in vitro. 10 Sep 2008
• [Matrix metalloproteinase 2 and 9 as the factor of head and neck tumor metastasis] 30 Aug 2008
• Matrix metalloproteinase-9/tissue inhibitors of metalloproteinase-1 expression and atrial structural remodeling in a dog model of atrial fibrillation: inhibition with angiotensin-converting enzyme. 13 Aug 2008
• [Effect of the sera of rabbits fed with Tongxinluo on MMP-9 and TIMP-1 expression and secretion in U937 monocyte-derived macrophages] 30 Jul 2008
• Soluble factors-mediated immunomodulatory effects of canine adipose tissue-derived mesenchymal stem cells. 30 Jul 2008

See a longer list of these articles.

Technical information about 'Tissue Inhibitor of Metalloproteinase-1'

Definition: A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a N-glycosylated protein, molecular weight 28 kD, produced by a vast range of cell types and found in a variety of tissues and body fluids. It has been shown to suppress metastasis and inhibit tumor invasion in vitro.

Registry Number: 0

Descriptor UI: D019715

Alternative terms: Tissue Inhibitor of Metalloproteinase-1; Metalloproteinase-1 Tissue Inhibitor; Tissue Inhibitor of Metalloproteinase 1; TIMP-1;

Allowable Qualifiers: blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis;

Tree Number: D12.776.926.450;

History Note: 98; see TISSUE-INHIBITOR OF METALLOPROTEINASE-1 (NM) 1980-97