Tissue Inhibitor of Metalloproteinase-1 - Genetics
Research News and Information

Sunday, November 22, 2009

Expression of matrix metalloproteinases MMP-2, MMP-9 and their tissue inhibitors TIMP-1 and TIMP-2 in the epithelium and stroma of salivary gland pleomorphic adenomas.

30 Aug 2009 AIMS: The balance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) is involved in the morphogenesis of normal salivary gland as well as in the mechanisms of tumour invasion and metastasis. The role of MMPs and TIMPs in ... Read more...

Differential regulation of blood vessel formation between standard and delayed bone healing.

30 Aug 2009 Blood vessel formation is a prerequisite for bone healing. In this study, we tested the hypothesis that a delay in bone healing is associated with an altered regulation of blood vessel formation. A tibial osteotomy was performed in two groups of ... Read more...

In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression.

30 Aug 2009 This study evaluated how dynamic compression induced changes in gene expression, tissue composition, and structural properties of the intervertebral disc using a rat tail model. We hypothesized that daily exposure to dynamic compression for short ... Read more...

Latest indexed articles for 'Tissue Inhibitor of Metalloproteinase-1 - Genetics'

These are the very latest articles for this heading:

• Expression of matrix metalloproteinases MMP-2, MMP-9 and their tissue inhibitors TIMP-1 and TIMP-2 in the epithelium and stroma of salivary gland pleomorphic adenomas. 30 Aug 2009
• Differential regulation of blood vessel formation between standard and delayed bone healing. 30 Aug 2009
• In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression. 30 Aug 2009
• Matrix metalloproteinases inhibition provides neuroprotection against hypoxia-ischemia in the developing brain. 25 Aug 2009
• Aspirin inhibits MMP-2 and MMP-9 expression and activity through PPARalpha/gamma and TIMP-1-mediated mechanisms in cultured mouse celiac macrophages. 30 Jul 2009
• MMP induced by Gr-1+ cells are crucial for recruitment of Th cells into the airways. 30 Jul 2009
• High levels of proinflammatory cytokines, but not markers of tissue injury, in unaffected intestinal areas from patients with IBD. 28 Jul 2009
• Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway. 14 Jul 2009
• Expression of MMP-7, MMP-9, TIMP-1 and TIMP-2 mRNA in lung tissue of patients with non-small cell lung cancer (NSCLC) and benign pulmonary disease. 29 Jun 2009
• Negative regulation of TIMP1 is mediated by transcription factor TWIST1. 29 Jun 2009
• Lack of TIMP-1 tumour cell immunoreactivity predicts effect of adjuvant anthracycline-based chemotherapy in patients (n=647) with primary breast cancer. A Danish Breast Cancer Cooperative Group Study. 13 Jun 2009
• 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells. 4 Jun 2009
• Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat. 2 Jun 2009
• [Effect of Huzhang on expression of lung fibroblasts' MMP-2/TIMP-1mRNA in pulmonary fibrosis rats] 30 May 2009
• Alterations in regulators of the extracellular matrix in non-Hodgkin lymphomas. 30 May 2009
• Tissue inhibitor of metalloproteinase-1 is an early marker of acute endothelial dysfunction in a rodent model of venous oxidative injury. 19 May 2009
• Thrombin regulates matrix metalloproteinase-9 expression in human monocytes. 16 May 2009
• Lack of TIMP-1 increases severity of experimental autoimmune encephalomyelitis: Effects of darbepoetin alfa on TIMP-1 null and wild-type mice. 7 May 2009
• TGF-beta1 gene silencing for treating liver fibrosis. 29 Apr 2009
• Tumour-associated tenascin-C isoforms promote breast cancer cell invasion and growth by matrix metalloproteinase-dependent and independent mechanisms. 28 Apr 2009

See a longer list of these articles.

Technical information about 'Tissue Inhibitor of Metalloproteinase-1'

Definition: A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a N-glycosylated protein, molecular weight 28 kD, produced by a vast range of cell types and found in a variety of tissues and body fluids. It has been shown to suppress metastasis and inhibit tumor invasion in vitro.

Registry Number: 0

Descriptor UI: D019715

Alternative terms: Tissue Inhibitor of Metalloproteinase-1; Metalloproteinase-1 Tissue Inhibitor; Tissue Inhibitor of Metalloproteinase 1; TIMP-1;

Allowable Qualifiers: blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis;

Tree Number: D12.776.926.450;

History Note: 98; see TISSUE-INHIBITOR OF METALLOPROTEINASE-1 (NM) 1980-97