Tissue Inhibitor of Metalloproteinase-1 - Metabolism
Research News and Information

Sunday, November 22, 2009

Expression of matrix metalloproteinases MMP-2, MMP-9 and their tissue inhibitors TIMP-1 and TIMP-2 in the epithelium and stroma of salivary gland pleomorphic adenomas.

30 Aug 2009 AIMS: The balance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) is involved in the morphogenesis of normal salivary gland as well as in the mechanisms of tumour invasion and metastasis. The role of MMPs and TIMPs in ... Read more...

In vivo characterization of doxycycline effects on tear metalloproteinases in patients with chronic blepharitis.

30 Aug 2009 PURPOSE: Matrix metalloproteinases (MMPs) have a role in the pathogenesis of rosacea-associated chronic blepharitis. Doxycycline is largely used as a treatment for recalcitrant chronic blepharitis. It has been shown in vitro that doxycycline ... Read more...

Matrix metalloproteinases inhibition provides neuroprotection against hypoxia-ischemia in the developing brain.

25 Aug 2009 The present study was designed to investigate the role of matrix metalloproteinases (MMPs) in the immature brain and the long term effects of early MMPs inhibition after hypoxic-ischemic (HI) injury. HI was induced by unilateral ligation of the ... Read more...

Latest indexed articles for 'Tissue Inhibitor of Metalloproteinase-1 - Metabolism'

These are the very latest articles for this heading:

• Expression of matrix metalloproteinases MMP-2, MMP-9 and their tissue inhibitors TIMP-1 and TIMP-2 in the epithelium and stroma of salivary gland pleomorphic adenomas. 30 Aug 2009
• In vivo characterization of doxycycline effects on tear metalloproteinases in patients with chronic blepharitis. 30 Aug 2009
• Matrix metalloproteinases inhibition provides neuroprotection against hypoxia-ischemia in the developing brain. 25 Aug 2009
• Angiotensin II receptor blockade improves matrix metalloproteinases/tissue inhibitor of matrix metalloproteinase-1 balance and restores fibronectin expression in rat infarcted myocardium. 16 Aug 2009
• Tissue inhibitor metalloproteinase type-1 (TIMP-1), a novel cancer biomarker predicting response of adjuvant anthracycline-based chemotherapy in patients afflicted with primary breast cancer. Aug 2009
• Therapeutic effect of topical 5-fluorouracil in conjunctival squamous carcinoma is associated with changes in matrix metalloproteinases and tissue inhibitor of metalloproteinases expression. 30 Jul 2009
• Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells. 30 Jul 2009
• Potential role of matrix metalloproteinase-2,-9 and tissue inhibitors of metalloproteinase-1,-2 in exudative pleural effusions. 30 Jul 2009
• Regulation of collagen turnover in human skin fibroblasts exposed to a gadolinium-based contrast agent. 30 Jul 2009
• Cancer cell growth and extracellular matrix remodeling mechanism of ascorbate; beneficial modulation by P. leucotomos. 30 Jul 2009
• Aspirin inhibits MMP-2 and MMP-9 expression and activity through PPARalpha/gamma and TIMP-1-mediated mechanisms in cultured mouse celiac macrophages. 30 Jul 2009
• MMP induced by Gr-1+ cells are crucial for recruitment of Th cells into the airways. 30 Jul 2009
• Potential effects of peroxisome proliferator-activated receptor activator on LPS-induced lung injury in rats. 30 Jul 2009
• Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway. 14 Jul 2009
• [Role of matrix metalloproteinases and their tissue inhibitor in the morphogenesis of chronic Helicobacter pylori-associated gastritis in children] 29 Jun 2009
• Neuronal TIMP-1 release accompanies astrocytic MMP-9 secretion and enhances astrocyte proliferation induced by beta-amyloid 25-35 fragment. 29 Jun 2009
• Negative regulation of TIMP1 is mediated by transcription factor TWIST1. 29 Jun 2009
• Response of extracellular matrix regulators in mouse lung after exposure to photons, protons and simulated solar particle event protons. 29 Jun 2009
• Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome. 29 Jun 2009
• Glomerular protein levels of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 are lower in diabetic subjects. 6 Jun 2009

See a longer list of these articles.

Technical information about 'Tissue Inhibitor of Metalloproteinase-1'

Definition: A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a N-glycosylated protein, molecular weight 28 kD, produced by a vast range of cell types and found in a variety of tissues and body fluids. It has been shown to suppress metastasis and inhibit tumor invasion in vitro.

Registry Number: 0

Descriptor UI: D019715

Alternative terms: Tissue Inhibitor of Metalloproteinase-1; Metalloproteinase-1 Tissue Inhibitor; Tissue Inhibitor of Metalloproteinase 1; TIMP-1;

Allowable Qualifiers: blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis;

Tree Number: D12.776.926.450;

History Note: 98; see TISSUE-INHIBITOR OF METALLOPROTEINASE-1 (NM) 1980-97