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Tourette Syndrome - Genetics
Research News and Information
Definition of 'Tourette Syndrome'A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or a general medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79) |
Sunday, November 22, 2009
Association of intronic variants of the BTBD9 gene with Tourette syndrome.
29 Sep 2009 
OBJECTIVE: To test the association between Tourette syndrome (TS) and genetic variants in genomic loci MEIS1, MAP2K5/LBXCOR1, and BTBD9, for which genome-wide association studies in restless legs syndrome and periodic limb movements during sleep ... Read more...
Thinning of the motor-cingulate-insular cortices in siblings concordant for Tourette syndrome.
7 Sep 2009 Fraternal twin studies on normal subjects have demonstrated low heritability (intra-class correlation coefficient) estimates for frontal brain regions (r = 0.43). Here we aimed to investigate the relatedness/similarity estimates of the frontal brain ... Read more...
Immunopathogenic mechanisms in tourette syndrome: A critical review.
13 Jul 2009 Tourette syndrome (TS) has a multifactorial etiology, in which genetic, environmental, immunological and hormonal factors interact to establish vulnerability. This review: (i) summarizes research exploring the exposure of TS patients to ... Read more...
Latest indexed articles for 'Tourette Syndrome - Genetics'
These are the very latest articles for this heading:
- Association of intronic variants of the BTBD9 gene with Tourette syndrome. 29 Sep 2009
- Thinning of the motor-cingulate-insular cortices in siblings concordant for Tourette syndrome. 7 Sep 2009
- Immunopathogenic mechanisms in tourette syndrome: A critical review. 13 Jul 2009
- Association of SLITRK1 to Gilles de la Tourette Syndrome. 3 Jun 2009
- COMT gene polymorphism association and drug response in Tourette syndrome.
30 May 2009 - The genetics of obsessive-compulsive disorder and Tourette's syndrome: what are the common factors? 30 Mar 2009
- Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome. 27 Feb 2009
- Chromosome 5 and Gilles de la Tourette syndrome: Linkage in a large pedigree and association study of six candidates in the region. 3 Jan 2009
- Sequence analysis of the complete SLITRK1 gene in Austrian patients with Tourette's disorder. 29 Nov 2008
- Consanguineous Iranian kindreds with severe Tourette syndrome. 28 Oct 2008
- The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 2: tentative explanations for differing prevalence figures in GTS, including the possible effects of psychopathology, aetiology, cultural differences, and differing phenotypes. 30 Sep 2008
- [Tourette syndrome. Genetics, neuroanatomy and neurotransmitters] 23 Aug 2008
- Psychopathological features of obsessive-compulsive disorder in an Italian family with Gilles de la Tourette syndrome not linked to the SLITRK1 gene. 19 Aug 2008
- Father-to-son transmission of 6;17 translocation in Tourette's syndrome. 30 Jul 2008
- Fragile X syndrome associated with tic disorders. 13 Jun 2008
- Haplotype evolution of SLITRK1, a candidate gene for Gilles de la Tourette syndrome. 3 Jun 2008
- Age-related gene expression in Tourette syndrome. 13 May 2008
- Regulation of DYT1 gene expression by the Ets family of transcription factors. 3 May 2008
- Lack of association between SLITRK1var321 and Tourette syndrome in a large family-based sample. 13 Apr 2008
- Screening of the epsilon sarcoglycan gene in Tourette syndrome and obsessive compulsive disorder. 30 Mar 2008
See a longer list of these articles.
Technical information about 'Tourette Syndrome'
Definition: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or a general medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)
Descriptor UI: D005879
Alternative terms: Tourette Syndrome; Combined Vocal and Multiple Motor Tic Disorder; Gilles de la Tourette Syndrome; Gilles de la Tourette's Disease; Tourette's Syndrome; Syndrome, Tourette's; Tourettes Syndrome; Tic Disorder, Combined Vocal and Multiple Motor; Tourette Disease; Tourette Disorder; Tourette's Disease; Tourettes Disease; Tourette's Disorder; Tourettes Disorder; Combined Multiple Motor and Vocal Tic Disorder; Multiple Motor and Vocal Tic Disorder, Combined;
Related Mesh Headings: Tics;
Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;
Tree Number: C10.228.140.079.898; C10.228.662.825.800; C10.574.500.850; C16.320.400.820; F03.550.825.850;
History Note: 1989(1966)