Transforming Growth Factor beta - Biosynthesis
Research News and Information

Saturday, November 21, 2009

Potassium inhibits dietary salt-induced transforming growth factor-beta production.

6 Sep 2009 Human and animal studies demonstrate an untoward effect of excess dietary NaCl (salt) intake on cardiovascular function and life span. The endothelium in particular augments the production of transforming growth factor (TGF)-beta, a fibrogenic ... Read more...

Dysfunctional transforming growth factor-beta receptor II accelerates prostate tumorigenesis in the TRAMP mouse model.

6 Sep 2009 The contribution of a dysfunctional transforming growth factor-beta type II receptor (TGF beta RII) to prostate cancer initiation and progression was investigated in an in vivo mouse model. Transgenic mice harboring the dominant-negative mutant ... Read more...

Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma.

30 Aug 2009 BACKGROUND: Both transforming growth factor (TGF)-beta(1) and activin-A have been implicated in airway remodeling in asthma, but the modulation of their specific signaling pathways after disease activation remains undefined. OBJECTIVE: To define the ... Read more...

Latest indexed articles for 'Transforming Growth Factor beta - Biosynthesis'

These are the very latest articles for this heading:

• Potassium inhibits dietary salt-induced transforming growth factor-beta production. 6 Sep 2009
• Dysfunctional transforming growth factor-beta receptor II accelerates prostate tumorigenesis in the TRAMP mouse model. 6 Sep 2009
• Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma. 30 Aug 2009
• CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta. 25 Jul 2009
• Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production. 12 Jul 2009
• Effect of transdermal electromotive drug therapy on fibrogenic cytokine expression in Peyronie's disease. 12 Jul 2009
• Cannabinoids inhibit fibrogenesis in diffuse systemic sclerosis fibroblasts. 7 Jul 2009
• Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses. 6 Jul 2009
• Gastroprotective effects of a new zinc(II)-curcumin complex against pylorus-ligature-induced gastric ulcer in rats. 5 Jul 2009
• Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats. 22 Jun 2009
• Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression. 20 Jun 2009
• The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes. 15 Jun 2009
• TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23. 4 Jun 2009
• Decreased catalase expression and increased susceptibility to oxidative stress in primary cultured corneal fibroblasts from patients with granular corneal dystrophy type II. 2 Jun 2009
• FOXP3-expressing CD4(+) T-cell numbers increase in areas of duodenal gastric metaplasia and are associated to CD4(+) T-cell aggregates in the duodenum of Helicobacter pylori-infected duodenal ulcer patients. 30 May 2009
• Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice. 24 May 2009
• Recipient genotype is a predictor of allograft cytokine expression and outcomes after pediatric cardiac transplantation. 17 May 2009
• The nematode parasite Onchocerca volvulus generates the transforming growth factor-beta (TGF-beta). 10 May 2009
• Compartmentalization of immune responses in human tuberculosis: few CD8+ effector T cells but elevated levels of FoxP3+ regulatory t cells in the granulomatous lesions. 10 May 2009
• Effect of praziquantel treatment on the expression of matrix metalloproteinases in relation to tissue resorption during fibrosis in hamsters with acute and chronic Opisthorchis viverrini infection. 5 May 2009

See a longer list of these articles.

Technical information about 'Transforming Growth Factor beta'

Definition: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

Registry Number: 0

Descriptor UI: D016212

Alternative terms: Transforming Growth Factor beta; Milk Growth Factor; Factor, Milk Growth; Growth Factor, Milk; TGF-beta; TGFbeta; Platelet Transforming Growth Factor; Bone-Derived Transforming Growth Factor; Bone Derived Transforming Growth Factor;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.374.687; D12.644.276.954.800.720; D12.644.276.963.720; D12.776.467.374.687; D12.776.467.942.800.720; D12.776.467.960.720; D23.529.374.687; D23.529.942.800.720; D23.529.960.720;

Online Note: use TRANSFORMING GROWTH FACTORS to search TRANSFORMING GROWTH FACTOR BETA & TGF-BETA 1989-90

History Note: 91; was see TRANSFORMING GROWTH FACTORS 1989-90; TGF-BETA was see TRANSFORMING GROWTH FACTORS 1989-90