Transforming Growth Factor beta - Genetics
Research News and Information

Saturday, November 21, 2009

Clinical and genetic profile of Avellino corneal dystrophy in 2 families from north India.

29 Sep 2009 OBJECTIVE: To report Avellino corneal dystrophy and underlying R124H mutation in 2 families of Indian origin. METHODS: Peripheral blood was collected in EDTA for genomic DNA isolation from leukocytes of all affected and unaffected individuals. ... Read more...

Lack of cardiac fibrosis in a new model of high prorenin hyperaldosteronism.

9 Sep 2009 The aim of the present study was to test the hypothesis that elevation of prorenin in plasma is sufficient to induce cardiac fibrosis. Normotensive cyp1a1ren-2 transgenic rats with normal plasma prorenin and aldosterone levels were given 0.125% ... Read more...

14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition.

6 Sep 2009 ErbB2, a metastasis-promoting oncoprotein, is overexpressed in approximately 25% of invasive/metastatic breast cancers, but in 50%-60% of noninvasive ductal carcinomas in situ (DCIS). It has been puzzling how a subset of ErbB2-overexpressing DCIS ... Read more...

Latest indexed articles for 'Transforming Growth Factor beta - Genetics'

These are the very latest articles for this heading:

• Clinical and genetic profile of Avellino corneal dystrophy in 2 families from north India. 29 Sep 2009
• Lack of cardiac fibrosis in a new model of high prorenin hyperaldosteronism. 9 Sep 2009
• 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. 6 Sep 2009
• Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN. 6 Sep 2009
• Novel regulation of Smad3 oligomerization and DNA binding by its linker domain. 6 Sep 2009
• Opposing effects of KLF5 on the transcription of MYC in epithelial proliferation in the context of transforming growth factor beta. 12 Aug 2009
• Plasmodium falciparum-mediated induction of human CD25Foxp3 CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFbeta. 12 Aug 2009
• Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. Aug 2009
• Rapid release of cytoplasmic IL-15 from tumor-associated macrophages is an initial and critical event in IL-12-initiated tumor regression. 30 Jul 2009
• The orphan nuclear receptor SHP attenuates renal fibrosis. 28 Jul 2009
• Epigenetic mechanisms of regulation of Foxp3 expression. 27 Jul 2009
• An integrative ChIP-chip and gene expression profiling to model SMAD regulatory modules. 15 Jul 2009
• Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis. 13 Jul 2009
• Effect of transdermal electromotive drug therapy on fibrogenic cytokine expression in Peyronie's disease. 12 Jul 2009
• Cannabinoids inhibit fibrogenesis in diffuse systemic sclerosis fibroblasts. 7 Jul 2009
• Interaction of the RhoA exchange factor Net1 with discs large homolog 1 protects it from proteasome-mediated degradation and potentiates Net1 activity. 6 Jul 2009
• A TGF-beta-induced gene, betaig-h3, is crucial for the apoptotic disappearance of the medial edge epithelium in palate fusion. 29 Jun 2009
• Overexpression and interactions of interleukin-10, transforming growth factor beta, and vascular endothelial growth factor in esophageal squamous cell carcinoma. 29 Jun 2009
• Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation. 29 Jun 2009
• Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Transforming Growth Factor beta'

Definition: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

Registry Number: 0

Descriptor UI: D016212

Alternative terms: Transforming Growth Factor beta; Milk Growth Factor; Factor, Milk Growth; Growth Factor, Milk; TGF-beta; TGFbeta; Platelet Transforming Growth Factor; Bone-Derived Transforming Growth Factor; Bone Derived Transforming Growth Factor;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.374.687; D12.644.276.954.800.720; D12.644.276.963.720; D12.776.467.374.687; D12.776.467.942.800.720; D12.776.467.960.720; D23.529.374.687; D23.529.942.800.720; D23.529.960.720;

Online Note: use TRANSFORMING GROWTH FACTORS to search TRANSFORMING GROWTH FACTOR BETA & TGF-BETA 1989-90

History Note: 91; was see TRANSFORMING GROWTH FACTORS 1989-90; TGF-BETA was see TRANSFORMING GROWTH FACTORS 1989-90