Transforming Growth Factor beta - Metabolism
Research News and Information

Saturday, November 21, 2009

Smad4: gatekeeper gene in head and neck squamous cell carcinoma.

17 Oct 2009 Unchecked cell growth is a hallmark of cancer. During oncogenesis, cancerous cells become resistant to the TGF-beta signaling pathway that usually keeps cell growth in check. The role of a critical mediator of this pathway, Smad4, in head and neck ... Read more...

Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility.

16 Oct 2009 Here we use intravital imaging to demonstrate a reversible transition to a motile state as breast cancer cells spread. Imaging primary tumours revealed heterogeneity in cell morphology and motility. Two distinct modes of motility were observed: ... Read more...

Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions.

13 Oct 2009 Pigment epithelium isolated from the eye possesses immunosuppressive properties such as regulatory T (Treg) cell induction; e.g., cultured retinal pigment epithelium (RPE) converts CD4(+) T cells into Treg cells in vitro. RPE constitutively ... Read more...

Latest indexed articles for 'Transforming Growth Factor beta - Metabolism'

These are the very latest articles for this heading:

• Smad4: gatekeeper gene in head and neck squamous cell carcinoma. 17 Oct 2009
• TGF-beta helps cells fly solo. 16 Oct 2009
• Localized and reversible TGFbeta signalling switches breast cancer cells from cohesive to single cell motility. 16 Oct 2009
• Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions. 13 Oct 2009
• Cutting Edge: Tumor-specific CD8+ T cells infiltrating prostatic tumors are induced to become suppressor cells. 13 Oct 2009
• Involvement of interleukin-15 and interleukin-21, two gamma-chain-related cytokines, in celiac disease. 5 Oct 2009
• Allogeneic induced human FOXP3(+)IFN-gamma(+) T cells exhibit selective suppressive capacity. 29 Sep 2009
• Mixing conditions for cell scaffolds affect the bone formation induced by bone engineering with human bone marrow stromal cells, beta-tricalcium phosphate granules, and rhBMP-2. 29 Sep 2009
• Attenuation of portal hypertension by natural taurine in rats with liver cirrhosis. 26 Sep 2009
• Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling. 23 Sep 2009
• 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. 6 Sep 2009
• Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells. 6 Sep 2009
• Novel regulation of Smad3 oligomerization and DNA binding by its linker domain. 6 Sep 2009
• Adenosine mediates transforming growth factor-beta 1 release in kidney glomeruli of diabetic rats. 4 Sep 2009
• Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation. 4 Sep 2009
• SnapShot: Convenient, comprehensive, and now clickable. 2 Sep 2009
• Thrombospondin-2 therapy ameliorates experimental glomerulonephritis via inhibition of cell proliferation, inflammation, and TGF-beta activation. 31 Aug 2009
• Transcriptional regulation of Foxp3 gene: multiple signal pathways on the road. 30 Aug 2009
• CD4+CD25+ regulatory T cells modulate human dendritic cell chemokines via multiple mechanisms: comment on the article by Kolar et al. 30 Aug 2009
• Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Transforming Growth Factor beta'

Definition: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

Registry Number: 0

Descriptor UI: D016212

Alternative terms: Transforming Growth Factor beta; Milk Growth Factor; Factor, Milk Growth; Growth Factor, Milk; TGF-beta; TGFbeta; Platelet Transforming Growth Factor; Bone-Derived Transforming Growth Factor; Bone Derived Transforming Growth Factor;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.374.687; D12.644.276.954.800.720; D12.644.276.963.720; D12.776.467.374.687; D12.776.467.942.800.720; D12.776.467.960.720; D23.529.374.687; D23.529.942.800.720; D23.529.960.720;

Online Note: use TRANSFORMING GROWTH FACTORS to search TRANSFORMING GROWTH FACTOR BETA & TGF-BETA 1989-90

History Note: 91; was see TRANSFORMING GROWTH FACTORS 1989-90; TGF-BETA was see TRANSFORMING GROWTH FACTORS 1989-90