Transforming Growth Factor beta - Pharmacology
Research News and Information

Sunday, November 22, 2009

Requirement of a dynein light chain in TGFbeta/Smad3 signaling.

29 Nov 2009 We have previously reported that the dynein light chain (DLC) km23-1 is required for Smad2-dependent TGFbeta signaling. Here we describe another member of the km23/DYNLRB/LC7/robl family of DLCs, termed km23-2, which is also involved in TGFbeta ... Read more...

Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells.

13 Oct 2009 IL-33, a new member of the IL-1 cytokine family, promotes Th2 inflammation, but evidence on the implications of this cytokine in asthma is lacking. IL-33 would be mainly expressed by structural cells, but whether proinflammatory cytokines modulate ... Read more...

Allogeneic induced human FOXP3(+)IFN-gamma(+) T cells exhibit selective suppressive capacity.

29 Sep 2009 Human induced CD4(+)CD25(+) T cells have been shown to express FOXP3, similar to naturally occurring Treg cells (nTreg). However, the suppressive capacity of these cells is still under debate. The current study was designed to investigate functional ... Read more...

Latest indexed articles for 'Transforming Growth Factor beta - Pharmacology'

These are the very latest articles for this heading:

• Requirement of a dynein light chain in TGFbeta/Smad3 signaling. 29 Nov 2009
• Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells. 13 Oct 2009
• Allogeneic induced human FOXP3(+)IFN-gamma(+) T cells exhibit selective suppressive capacity. 29 Sep 2009
• Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. 26 Sep 2009
• Overexpression of FOXG1 contributes to TGF-beta resistance through inhibition of p21WAF1/CIP1 expression in ovarian cancer. 13 Sep 2009
• Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. 13 Sep 2009
• Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. 6 Sep 2009
• Rac1 promotes TGF-beta-stimulated mesangial cell type I collagen expression through a PI3K/Akt-dependent mechanism. 31 Aug 2009
• Characterization of the chondrocyte actin cytoskeleton in living three-dimensional culture: response to anabolic and catabolic stimuli. 30 Aug 2009
• Pretreatment of distraction docking sites with bone morphogenetic protein (rhBMP-2). 30 Aug 2009
• Pivotal, randomized, parallel evaluation of recombinant human bone morphogenetic protein-2/absorbable collagen sponge and autogenous bone graft for maxillary sinus floor augmentation. 30 Aug 2009
• Sox9 represses alpha-sarcoglycan gene expression in early myogenic differentiation. 29 Aug 2009
• De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid. 26 Aug 2009
• Characterisation of K+ currents in the C8-B4 microglial cell line and their regulation by microglia activating stimuli. Aug 2009
• Intercellular communication of cellular stress monitored by gamma-H2AX induction. Aug 2009
• TGF-beta promotes invasion and metastasis of gastric cancer cells by increasing fascin1 expression via ERK and JNK signal pathways. 30 Jul 2009
• Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. 26 Jul 2009
• Promoter-wide analysis of Smad4 binding sites in human epithelial cells. 21 Jul 2009
• Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis. 19 Jul 2009
• Transcriptome profiling reveals TGF-beta signaling involvement in epileptogenesis. 13 Jul 2009

See a longer list of these articles.

Technical information about 'Transforming Growth Factor beta'

Definition: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

Registry Number: 0

Descriptor UI: D016212

Alternative terms: Transforming Growth Factor beta; Milk Growth Factor; Factor, Milk Growth; Growth Factor, Milk; TGF-beta; TGFbeta; Platelet Transforming Growth Factor; Bone-Derived Transforming Growth Factor; Bone Derived Transforming Growth Factor;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.374.687; D12.644.276.954.800.720; D12.644.276.963.720; D12.776.467.374.687; D12.776.467.942.800.720; D12.776.467.960.720; D23.529.374.687; D23.529.942.800.720; D23.529.960.720;

Online Note: use TRANSFORMING GROWTH FACTORS to search TRANSFORMING GROWTH FACTOR BETA & TGF-BETA 1989-90

History Note: 91; was see TRANSFORMING GROWTH FACTORS 1989-90; TGF-BETA was see TRANSFORMING GROWTH FACTORS 1989-90