Transforming Growth Factor beta - Physiology
Research News and Information

Monday, November 23, 2009

Requirement of a dynein light chain in TGFbeta/Smad3 signaling.

29 Nov 2009 We have previously reported that the dynein light chain (DLC) km23-1 is required for Smad2-dependent TGFbeta signaling. Here we describe another member of the km23/DYNLRB/LC7/robl family of DLCs, termed km23-2, which is also involved in TGFbeta ... Read more...

Complex and context dependent regulation of hematopoiesis by TGF-beta superfamily signaling.

30 Aug 2009 The transforming growth factor (TGF)-beta superfamily of growth factors, including the TGF-betas, activins, and bone morphogenetic proteins (BMPs), provide cells with a broad spectrum of regulatory signals through the intracellular Smad pathway. ... Read more...

Down-regulation of transforming growth factor beta receptor type III in hepatocellular carcinoma is not directly associated with genetic alterations or loss of heterozygosity.

30 Aug 2009 The transforming growth factor receptor III (TGFbetaRIII) is the most abundant and essential TGF-beta binding protein that functions as a co-receptor with other receptors in TGF-beta signaling. In earlier studies, expression of TGFbetaRIII was ... Read more...

Latest indexed articles for 'Transforming Growth Factor beta - Physiology'

These are the very latest articles for this heading:

• Requirement of a dynein light chain in TGFbeta/Smad3 signaling. 29 Nov 2009
• TGF-beta helps cells fly solo. 16 Oct 2009
• Complex and context dependent regulation of hematopoiesis by TGF-beta superfamily signaling. 30 Aug 2009
• Down-regulation of transforming growth factor beta receptor type III in hepatocellular carcinoma is not directly associated with genetic alterations or loss of heterozygosity. 30 Aug 2009
• The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling. 22 Aug 2009
• Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition. 22 Aug 2009
• Scleroderma. 18 Aug 2009
• Bladder stromal loss of transforming growth factor receptor II decreases fibrosis after bladder obstruction. 16 Aug 2009
• Transforming growth factor beta isoforms regulation of Akt activity and XIAP levels in rat endometrium during estrous cycle, in a model of pseudopregnancy and in cultured decidual cells. 3 Aug 2009
• Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties. 2 Aug 2009
• Acceleration of palatal wound healing in Smad3-deficient mice. 30 Jul 2009
• The orphan nuclear receptor SHP attenuates renal fibrosis. 28 Jul 2009
• The role of transforming growth factor beta in cervical remodeling within the rat cervix. 22 Jul 2009
• Marfan syndrome and its disorder in periodontal tissues. 13 Jul 2009
• Human epithelial ovarian carcinoma cell-derived cytokines cooperatively induce activated CD4+CD25-CD45RA+ naïve T cells to express forkhead box protein 3 and exhibit suppressive ability in vitro. 8 Jul 2009
• Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses. 6 Jul 2009
• [Signaling mechanism underlying myelination in peripheral nervous system] 29 Jun 2009
• A TGF-beta-induced gene, betaig-h3, is crucial for the apoptotic disappearance of the medial edge epithelium in palate fusion. 29 Jun 2009
• TGFbeta regulation of membrane mucin Muc4 via proteosome degradation. 29 Jun 2009
• Insights into signaling and function of hematopoietic stem cells at the single-cell level. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Transforming Growth Factor beta'

Definition: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

Registry Number: 0

Descriptor UI: D016212

Alternative terms: Transforming Growth Factor beta; Milk Growth Factor; Factor, Milk Growth; Growth Factor, Milk; TGF-beta; TGFbeta; Platelet Transforming Growth Factor; Bone-Derived Transforming Growth Factor; Bone Derived Transforming Growth Factor;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.374.687; D12.644.276.954.800.720; D12.644.276.963.720; D12.776.467.374.687; D12.776.467.942.800.720; D12.776.467.960.720; D23.529.374.687; D23.529.942.800.720; D23.529.960.720;

Online Note: use TRANSFORMING GROWTH FACTORS to search TRANSFORMING GROWTH FACTOR BETA & TGF-BETA 1989-90

History Note: 91; was see TRANSFORMING GROWTH FACTORS 1989-90; TGF-BETA was see TRANSFORMING GROWTH FACTORS 1989-90