Transforming Growth Factor beta1
Research News and Information

Saturday, November 21, 2009

Correlation between anti-fibrotic effect of baicalin and serum cytokines in rat hepatic fibrosis.

5 Oct 2009 AIM: To investigate the correlation between the antifibrotic effect of baicalin and serum cytokine production in rat hepatic fibrosis. METHODS: Forty male Sprague-Dawley rats were divided randomly into four groups: normal control group, model group, ... Read more...

IL-10 and TGF-beta1 are associated with variations in fluke burdens following experimental fasciolosis in sheep.

29 Sep 2009 Infection with Fasciola hepatica causes an economically important disease in ruminants. Variability in parasite load may indicate innate differences in the host immune system. This study aimed to investigate the immunological mechanisms that are ... Read more...

Anabolic actions of IGF-I and TGF-beta1 on Interleukin-1beta-treated human articular chondrocytes: evaluation in two and three dimensional cultures.

29 Sep 2009 Pro-inflammatory cytokines, such as interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) play a key role in the pathogenesis of Osteoarthritis (OA). The aim of this study was to investigate the potential anti-inflammatory ... Read more...

Latest indexed articles for 'Transforming Growth Factor beta1'

These are the very latest articles for this heading:

• Correlation between anti-fibrotic effect of baicalin and serum cytokines in rat hepatic fibrosis. 5 Oct 2009
• IL-10 and TGF-beta1 are associated with variations in fluke burdens following experimental fasciolosis in sheep. 29 Sep 2009
• Anabolic actions of IGF-I and TGF-beta1 on Interleukin-1beta-treated human articular chondrocytes: evaluation in two and three dimensional cultures. 29 Sep 2009
• Inhibition of transforming growth factor beta receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation. 29 Sep 2009
• Identification of epistasis in ischemic stroke using multifactor dimensionality reduction and entropy decomposition. 28 Sep 2009
• Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right. 26 Sep 2009
• TGF-beta enforces senescence in Myc-transformed hematopoietic tumor cells through induction of Mad1 and repression of Myc activity. 15 Sep 2009
• Functional impact of sequence variation in the promoter region of TGFB1. 13 Sep 2009
• Hypoxia reduces TGFbeta1-induced corneal keratocyte myofibroblast transformation. 9 Sep 2009
• Differential regulation of E-cadherin and alpha-smooth muscle actin by BMP 7 in human renal proximal tubule epithelial cells and its implication in renal fibrosis. 7 Sep 2009
• Genetic modifiers of liver disease in cystic fibrosis. 7 Sep 2009
• Insulin receptor substrate-1 suppresses transforming growth factor-beta1-mediated epithelial-mesenchymal transition. 6 Sep 2009
• Molecular determinants of the profibrogenic effects of endothelin-1 in pancreatic stellate cells. 5 Sep 2009
• Neuropilin-1 and neuropilin-2 are differentially expressed in human proteinuric nephropathies and cytokine-stimulated proximal tubular cells. 5 Sep 2009
• Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. 2 Sep 2009
• Improved cartilage regeneration utilizing mesenchymal stem cells in TGF-beta1 gene-activated scaffolds. 30 Aug 2009
• Loss of peroxisome proliferator-activated receptor gamma in mouse fibroblasts results in increased susceptibility to bleomycin-induced skin fibrosis. 30 Aug 2009
• CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer. 30 Aug 2009
• The role of NF-kappaB and Smad3 in TGF-beta-mediated Foxp3 expression. 30 Aug 2009
• News from DNA and cell biology. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Transforming Growth Factor beta1'

Definition: A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.

Registry Number: 0

Descriptor UI: D053773

Alternative terms: Transforming Growth Factor beta1; Transforming Growth Factor beta I; TGF-beta1; TGF-beta-1; TGF beta 1; Transforming Growth Factor beta 1 Latency Associated Peptide; TGF-beta1 Latency-Associated Protein; Latency-Associated Protein, TGF-beta1; TGF beta1 Latency Associated Protein; TGF-beta1LAP; TGF beta1LAP;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.374.687.100; D12.644.276.954.800.720.100; D12.644.276.963.720.100; D12.776.467.374.687.100; D12.776.467.942.800.720.100; D12.776.467.960.720.100; D23.529.374.687.100; D23.529.942.800.720.100; D23.529.960.720.100;

History Note: 2007(1992)