Tretinoin - Metabolism
Research News and Information

Monday, November 23, 2009

Progressive interdigital cell death: regulation by the antagonistic interaction between fibroblast growth factor 8 and retinoic acid.

30 Oct 2009 The complete cohort of molecules involved in interdigital cell death (ICD) and their interactions are yet to be defined. Bmp proteins, retinoic acid (RA) and Fgf8 have been previously identified as relevant factors in the control of ICD. Here we ... Read more...

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.

25 Sep 2009 The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days ... Read more...

Signaling "cross-talk" is integrated by transcription factors in the development of the anterior segment in the eye.

30 Aug 2009 Extracellular signaling "cross-talk" between tissues is an important requirement for development of many organs yet the underlying mechanisms generally remain poorly understood. The anterior segment of the eye, which is constructed from four ... Read more...

Latest indexed articles for 'Tretinoin - Metabolism'

These are the very latest articles for this heading:

• Progressive interdigital cell death: regulation by the antagonistic interaction between fibroblast growth factor 8 and retinoic acid. 30 Oct 2009
• Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation. 25 Sep 2009
• Signaling "cross-talk" is integrated by transcription factors in the development of the anterior segment in the eye. 30 Aug 2009
• A highly conserved retinoic acid responsive element controls wt1a expression in the zebrafish pronephros. 30 Aug 2009
• A possible contribution of retinoids to regulation of fetal B lymphopoiesis. 30 Aug 2009
• Metabolism and regulation of gene expression by 4-oxoretinol versus all-trans retinoic acid in normal human mammary epithelial cells. 30 Aug 2009
• Regression of polypoid nasal mucosa after systemic corticosteroid therapy: a proteomics study. 29 Aug 2009
• In vitro characterization of Synechocystis CYP120A1 revealed the first nonanimal retinoic acid hydroxylase. 22 Aug 2009
• Male-specific expression of Aldh1a1 in mouse and chicken fetal testes: implications for retinoid balance in gonad development. 30 Jul 2009
• Induction of Wnt5a-expressing mesenchymal cells adjacent to the cloacal plate is an essential process for its proximodistal elongation and subsequent anorectal development. 30 Jul 2009
• The role of CYP26 enzymes in retinoic acid clearance. 30 Jul 2009
• Retinoid-responsive transcriptional changes in epidermal keratinocytes. 30 Jul 2009
• All-trans retinoic acid promotes neural lineage entry by pluripotent embryonic stem cells via multiple pathways. 28 Jul 2009
• Limb development: the rise and fall of retinoic acid. 26 Jul 2009
• Transglutaminase 2 and nucleoside diphosphate kinase activity are correlated in epithelial membranes and are abnormal in cystic fibrosis. 16 Jul 2009
• Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning. 13 Jul 2009
• The efficacy of an IL-1alpha vaccine depends on IL-1RI availability and concomitant myeloid-derived suppressor cell reduction. 29 Jun 2009
• Proteomic analysis of naphthalene-induced airway epithelial injury and repair in a cystic fibrosis mouse model. 29 Jun 2009
• Function of retinoid acid receptor alpha and p21 in all-trans-retinoic acid-induced acute T-lymphoblastic leukemia apoptosis. 29 Jun 2009
• BDNF and extracellular matrix regulate differentiation of mice neurosphere-derived cells into a GABAergic neuronal phenotype. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Tretinoin'

Definition: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).

Chemical name: Retinoic acid

Registry Number: 302-79-4

Descriptor UI: D014212

Alternative terms: Tretinoin; Vitamin A Acid; Acid, Vitamin A; trans-Retinoic Acid; Acid, trans-Retinoic; trans Retinoic Acid; all-trans-Retinoic Acid; Acid, all-trans-Retinoic; all trans Retinoic Acid; Retinoic Acid; Acid, Retinoic; Retin-A; Retin A; Vesanoid; Tretinoin Sodium Salt; Salt, Tretinoin Sodium; Sodium Salt, Tretinoin; Tretinoin Zinc Salt; Salt, Tretinoin Zinc; Zinc Salt, Tretinoin; beta-all-trans-Retinoic Acid; Acid, beta-all-trans-Retinoic; beta all trans Retinoic Acid; Tretinoin Potassium Salt; Potassium Salt, Tretinoin; Salt, Tretinoin Potassium;

Related Mesh Headings: Receptors, Retinoic Acid;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; physiology;

Pharmacological Action: Antineoplastic Agents; Keratolytic Agents;

Tree Number: D02.455.326.271.665.202.495.818.500; D02.455.426.392.368.367.379.249.700.860.500; D02.455.849.131.495.818.800; D23.767.261.700.780;

History Note: 80(75); was see under VITAMIN A 1975-79