Tretinoin - Pharmacology
Research News and Information

Sunday, November 22, 2009

Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos.

29 Sep 2009 Hox and Cdx transcription factors regulate embryonic positional identities. Cdx mutant mice display posterior body truncations of the axial skeleton, neuraxis, and caudal urorectal structures. We show that trunk Hox genes stimulate axial extension, ... Read more...

Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells.

29 Sep 2009 Our study explored the drug interaction of all-trans retinoic acid (ATRA) and RAD001 (everolimus), the inhibitor of mammalian target of rapamycin complex 1 (mTORC1), in acute myelogenous leukemia (AML) NB4 and HL60 cells. RAD001 (10 nM) ... Read more...

Developmental basis of the rostro-caudal organization of the brainstem respiratory rhythm generator.

10 Sep 2009 The Hox genetic network plays a key role in the anteroposterior patterning of the rhombencephalon at pre- and early-segmental stages of development of the neural tube. In the mouse, it controls development of the entire brainstem respiratory ... Read more...

Latest indexed articles for 'Tretinoin - Pharmacology'

These are the very latest articles for this heading:

• Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. 29 Sep 2009
• Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells. 29 Sep 2009
• Developmental basis of the rostro-caudal organization of the brainstem respiratory rhythm generator. 10 Sep 2009
• Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. 6 Sep 2009
• Retinoic acid-induced nNOS expression depends on a novel PI3K/Akt/DAX1 pathway in human TGW-nu-I neuroblastoma cells. 31 Aug 2009
• Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells. 30 Aug 2009
• A possible contribution of retinoids to regulation of fetal B lymphopoiesis. 30 Aug 2009
• Metabolism and regulation of gene expression by 4-oxoretinol versus all-trans retinoic acid in normal human mammary epithelial cells. 30 Aug 2009
• De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid. 26 Aug 2009
• The regulatory role of cell mechanics for migration of differentiating myeloid cells. 24 Aug 2009
• Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene. 12 Aug 2009
• Statins, fibrates and retinoic acid upregulate mitochondrial acylcarnitine carrier gene expression. 4 Aug 2009
• Analysis of Rex1 (zfp42) function in embryonic stem cell differentiation. 30 Jul 2009
• ICAT as a potential enhancer of monocytic differentiation: implications from the comparative proteome analysis of the HL60 cell line stimulated by all-trans retinoic acid and NSC67657. 30 Jul 2009
• Loss of anti-proliferative effect of all-trans retinoic acid in advanced stage of breast carcinogenesis. 30 Jul 2009
• The T helper 17-regulatory T cell axis in transplant rejection and tolerance. 30 Jul 2009
• Response of retinoic acid-resistant KG1 cells to combination of retinoic acid with diverse histone deacetylase inhibitors. 30 Jul 2009
• Retinoid-responsive transcriptional changes in epidermal keratinocytes. 30 Jul 2009
• c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic acid-induced cell differentiation and G0 arrest. 25 Jul 2009
• Repression of Ca2+/calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells. 22 Jul 2009

See a longer list of these articles.

Technical information about 'Tretinoin'

Definition: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).

Chemical name: Retinoic acid

Registry Number: 302-79-4

Descriptor UI: D014212

Alternative terms: Tretinoin; Vitamin A Acid; Acid, Vitamin A; trans-Retinoic Acid; Acid, trans-Retinoic; trans Retinoic Acid; all-trans-Retinoic Acid; Acid, all-trans-Retinoic; all trans Retinoic Acid; Retinoic Acid; Acid, Retinoic; Retin-A; Retin A; Vesanoid; Tretinoin Sodium Salt; Salt, Tretinoin Sodium; Sodium Salt, Tretinoin; Tretinoin Zinc Salt; Salt, Tretinoin Zinc; Zinc Salt, Tretinoin; beta-all-trans-Retinoic Acid; Acid, beta-all-trans-Retinoic; beta all trans Retinoic Acid; Tretinoin Potassium Salt; Potassium Salt, Tretinoin; Salt, Tretinoin Potassium;

Related Mesh Headings: Receptors, Retinoic Acid;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; physiology;

Pharmacological Action: Antineoplastic Agents; Keratolytic Agents;

Tree Number: D02.455.326.271.665.202.495.818.500; D02.455.426.392.368.367.379.249.700.860.500; D02.455.849.131.495.818.800; D23.767.261.700.780;

History Note: 80(75); was see under VITAMIN A 1975-79