Tretinoin
Research News and Information

Sunday, November 22, 2009

Treatment of children with acute promyelocytic leukemia: results of the first North American Intergroup trial INT0129.

29 Nov 2009 BACKGROUND: This report focuses on the children enrolled on the first North American Intergroup study of APL (INT0129). This study was designed to compare the rates of CR, disease-free survival (DFS), overall survival (OS) and toxicity of therapy ... Read more...

Progressive interdigital cell death: regulation by the antagonistic interaction between fibroblast growth factor 8 and retinoic acid.

30 Oct 2009 The complete cohort of molecules involved in interdigital cell death (ICD) and their interactions are yet to be defined. Bmp proteins, retinoic acid (RA) and Fgf8 have been previously identified as relevant factors in the control of ICD. Here we ... Read more...

Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos.

29 Sep 2009 Hox and Cdx transcription factors regulate embryonic positional identities. Cdx mutant mice display posterior body truncations of the axial skeleton, neuraxis, and caudal urorectal structures. We show that trunk Hox genes stimulate axial extension, ... Read more...

Latest indexed articles for 'Tretinoin'

These are the very latest articles for this heading:

• Treatment of children with acute promyelocytic leukemia: results of the first North American Intergroup trial INT0129. 29 Nov 2009
• Progressive interdigital cell death: regulation by the antagonistic interaction between fibroblast growth factor 8 and retinoic acid. 30 Oct 2009
• Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. 29 Sep 2009
• Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells. 29 Sep 2009
• Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation. 25 Sep 2009
• Developmental basis of the rostro-caudal organization of the brainstem respiratory rhythm generator. 10 Sep 2009
• Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. 6 Sep 2009
• Retinoic acid-induced nNOS expression depends on a novel PI3K/Akt/DAX1 pathway in human TGW-nu-I neuroblastoma cells. 31 Aug 2009
• Smad2/3 is involved in growth inhibition of mouse embryonic palate mesenchymal cells induced by all-trans retinoic acid. 30 Aug 2009
• Signaling "cross-talk" is integrated by transcription factors in the development of the anterior segment in the eye. 30 Aug 2009
• A highly conserved retinoic acid responsive element controls wt1a expression in the zebrafish pronephros. 30 Aug 2009
• Hydroxychloroquine, chloroquine, and all-trans retinoic acid regulate growth, survival, and histone acetylation in breast cancer cells. 30 Aug 2009
• Tretinoin: an established long-term safety profile. 30 Aug 2009
• Hyperpigmentation: old problem, new therapies. 30 Aug 2009
• Benefits of using a hydroquinone/tretinoin skin care system in patients undergoing intense pulsed light therapy for photorejuvenation: a placebo-controlled study. 30 Aug 2009
• A possible contribution of retinoids to regulation of fetal B lymphopoiesis. 30 Aug 2009
• Tailoring treatment strategy for acute promyelocytic leukemia in low-income countries. 30 Aug 2009
• Improved outcome for Chinese children with acute promyelocytic leukemia: a comparison of two protocols. 30 Aug 2009
• Metabolism and regulation of gene expression by 4-oxoretinol versus all-trans retinoic acid in normal human mammary epithelial cells. 30 Aug 2009
• Regression of polypoid nasal mucosa after systemic corticosteroid therapy: a proteomics study. 29 Aug 2009

See a longer list of these articles.

Technical information about 'Tretinoin'

Definition: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).

Chemical name: Retinoic acid

Registry Number: 302-79-4

Descriptor UI: D014212

Alternative terms: Tretinoin; Vitamin A Acid; Acid, Vitamin A; trans-Retinoic Acid; Acid, trans-Retinoic; trans Retinoic Acid; all-trans-Retinoic Acid; Acid, all-trans-Retinoic; all trans Retinoic Acid; Retinoic Acid; Acid, Retinoic; Retin-A; Retin A; Vesanoid; Tretinoin Sodium Salt; Salt, Tretinoin Sodium; Sodium Salt, Tretinoin; Tretinoin Zinc Salt; Salt, Tretinoin Zinc; Zinc Salt, Tretinoin; beta-all-trans-Retinoic Acid; Acid, beta-all-trans-Retinoic; beta all trans Retinoic Acid; Tretinoin Potassium Salt; Potassium Salt, Tretinoin; Salt, Tretinoin Potassium;

Related Mesh Headings: Receptors, Retinoic Acid;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; physiology;

Pharmacological Action: Antineoplastic Agents; Keratolytic Agents;

Tree Number: D02.455.326.271.665.202.495.818.500; D02.455.426.392.368.367.379.249.700.860.500; D02.455.849.131.495.818.800; D23.767.261.700.780;

History Note: 80(75); was see under VITAMIN A 1975-79