Tryptamines - Pharmacology
Research News and Information

Monday, November 23, 2009

Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands.

21 Oct 2009 TAARs (trace amine-associated receptors) are G-protein-coupled receptors that respond to low abundance, endogenous amines such as tyramine and tryptamine, and represent potential targets for neuropsychiatric diseases. However, some members of this ... Read more...

Neuroprotection by melatonin on astrocytoma cell death.

30 Jul 2009 Glial cells play an active role in the homeostatic regulation of the central nervous system (CNS). Astrocytes, the most abundant glial cell types in the brain, provide mechanical and metabolic support for neurons. The regulation of astrocyte ... Read more...

5-MCA-NAT does not act through NQO2 to reduce intraocular pressure in New-Zealand white rabbit.

14 Jul 2009 Solid data support the idea that the MT(3) melatonin binding site is an enzyme, quinone reductase 2 (NQO2), rather than a membrane melatonin receptor. However, the melatonin analogue, 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT), reduces ... Read more...

Latest indexed articles for 'Tryptamines - Pharmacology'

These are the very latest articles for this heading:

• Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands. 21 Oct 2009
• Neuroprotection by melatonin on astrocytoma cell death. 30 Jul 2009
• 5-MCA-NAT does not act through NQO2 to reduce intraocular pressure in New-Zealand white rabbit. 14 Jul 2009
• An unexpected effect of 5-MCA-NAT in chick retinal development. 7 Jul 2009
• A tryptamine derivative, SST-VEDI-1, inhibits apoptosis and stimulates mineralization in osteoblasts. 18 May 2009
• Tryptophan-dependent indole-3-acetic acid biosynthesis by 'IAA-synthase' proceeds via indole-3-acetamide. 2 Mar 2009
• Transcranial Doppler evaluation in migraineurs. 27 Feb 2009
• Allodynia-associated symptoms, pain intensity and time to treatment: predicting treatment response in acute migraine intervention. 9 Feb 2009
• WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation. 30 Jan 2009
• Nitric oxide synthase inhibition by pentacycloundecane conjugates of aminoguanidine and tryptamine. 30 Jan 2009
• Ten years of rizatriptan: from development to clinical science and future directions. 30 Jan 2009
• A new synthetic compound, SST-VEDI-1, inhibits osteoblast differentiation with a down-regulation of the Osterix expression. 6 Dec 2008
• Migraine, allodynia, and implications for treatment. 29 Nov 2008
• Male-specific induction of CYP3A2 in rats by zolmitriptan. 29 Nov 2008
• Melatonin protects against experimental reflux esophagitis. 26 Nov 2008
• CGRP-receptor antagonism in migraine treatment. 23 Nov 2008
• Ophthalmic formulations of the intraocular hypotensive melatonin agent 5-MCA-NAT. 12 Nov 2008
• Hallucinogens as discriminative stimuli in animals: LSD, phenethylamines, and tryptamines. 30 Oct 2008
• Variations in functional activity of the hormone-sensitive adenylate cyclase system in tissues of gastropod mollusks with streptozotocin-induced diabetes. 29 Sep 2008
• Selective activation of melatonin receptors with ramelteon improves liver function and hepatic perfusion after hemorrhagic shock in rat. 29 Sep 2008

See a longer list of these articles.

Technical information about 'Tryptamines'

Definition: Decarboxylated monoamine derivatives of TRYPTOPHAN.

Registry Number: 0

Descriptor UI: D014363

Alternative terms: Tryptamines; Indolylethylamines; Triptans;

Related Mesh Headings: Receptors, Serotonin;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; biosynthesis; physiology;

Tree Number: D02.092.211.215.801; D03.438.473.914;

History Note: 66(64)