Tumor Necrosis Factors - Biosynthesis
Research News and Information

Sunday, November 22, 2009

1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells.

16 Apr 2009 Glucocorticoid-induced TNF receptor ligand (GITRL), a prominent member of the TNF superfamily, activates its receptor on both effector and regulatory T cells to generate critical costimulatory signals that have been implicated in a wide range of ... Read more...

Developmental regulation of sensory neurite growth by the tumor necrosis factor superfamily member LIGHT.

9 Feb 2009 In a PCR screen to identify novel cytokine candidates involved in neuronal development, we identified transcripts for the tumor necrosis factor superfamily member 14 (TNFSF14), generally known as LIGHT (lymphotoxin-related inducible ligand that ... Read more...

Migration inhibitory factor (MIF) released by macrophages upon recognition of immune complexes is critical to inflammation in Arthus reaction.

31 Jan 2009 Deposition of immune complexes (IC) triggers Fc gamma R-dependent inflammation, leading to tissue damage in rheumatoid arthritis, systemic lupus erythematous, immune glomerulonephritis, and several immune vasculitides. Evidences support a role for ... Read more...

Latest indexed articles for 'Tumor Necrosis Factors - Biosynthesis'

These are the very latest articles for this heading:

• 1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells. 16 Apr 2009
• Developmental regulation of sensory neurite growth by the tumor necrosis factor superfamily member LIGHT. 9 Feb 2009
• Migration inhibitory factor (MIF) released by macrophages upon recognition of immune complexes is critical to inflammation in Arthus reaction. 31 Jan 2009
• Glucocorticoid-induced tumor necrosis factor receptor-related protein ligand subverts immunosurveillance of acute myeloid leukemia in humans. 18 Jan 2009
• TWEAK is expressed at the cell surface of monocytes during multiple sclerosis. 20 Oct 2008
• Possible involvement of long chain fatty acids in the spores of Ganoderma lucidum (Reishi Houshi) to its anti-tumor activity. 29 Sep 2008
• Expression of OX40 ligand in microglia activated by IFN-gamma sustains a protective CD4+ T-cell response in vitro. 13 May 2008
• IFN-gamma- and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers. 30 Mar 2008
• TNF superfamily member TWEAK exacerbates inflammation and demyelination in the cuprizone-induced model. 16 Jan 2008
• TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease. 3 Nov 2007
• Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo. 13 Sep 2007
• Reversal of LPS induced endothelial cell TNF synthesis and increased permeability with microencapsulated antisense oligomers to NF-kappaB. 30 Aug 2007
• [Effect of viruses on the host cytokine system] 29 Jun 2007
• Redirection of cytokine production by lymphocytes from women with pre-term delivery by dydrogesterone. 29 Jun 2007
• Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages. 11 May 2007
• Carvedilol, a nonselective beta-blocker, suppresses the production of tumor necrosis factor and tissue factor by inhibiting early growth response factor-1 expression in human monocytes in vitro. 30 Mar 2007
• Restoration by dietary glutamine of reduced tumor necrosis factor production in a low-protein-diet-fed rat model. 5 Feb 2007
• [Effects of nuclear factor-kappaB decoy oligodeoxynucleotide on the function of human umbilical artery smooth muscle cells induced by umbilical sera in preeclampsia] 30 Jan 2007
• [Effects of immunosuppressants on cytokine expressions after repair for nerve injury in a rat model] 29 Nov 2006
• NF-kappaB signalling in cerebral ischaemia. 29 Nov 2006

See a longer list of these articles.

Technical information about 'Tumor Necrosis Factors'

Definition: A family of proteins that were originally identified by their ability to cause NECROSIS of NEOPLASMS. Their necrotic effect on cells is mediated through TUMOR NECROSIS FACTOR RECEPTORS which induce APOPTOSIS.

Registry Number: 0

Descriptor UI: D048069

Alternative terms: Tumor Necrosis Factors; Necrosis Factors, Tumor; TNF Receptor Ligands; Receptor Ligands, TNF; Tumor Necrosis Factor Superfamily Ligands;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.644.276.374.750; D12.644.276.972; D12.776.467.374.750; D12.776.467.972; D23.529.374.750; D23.529.972;

History Note: 2005