Tumor Suppressor Protein p53 - Metabolism
Research News and Information

Saturday, March 20, 2010

Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1).

29 Nov 2009 Osteosarcomas are the most prevalent primary bone tumors found in pediatric patients. To understand their molecular etiology, cell culture models are used to define disease mechanisms under controlled conditions. Many osteosarcoma cell lines (e.g., ... Read more...

The reduction of cell death and proliferation by p27(Kip1) minimizes DNA damage in an experimental model of genotoxicity.

13 Nov 2009 Hepatocellular carcinoma (HCC) is the fifth most commonly occurring cancer worldwide. The expression of p27 has been related to reduced severity of tumor grade and recurrence of HCC. The study assessed the role of p27 on the cell proliferation and ... Read more...

Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model.

13 Nov 2009 Cisplatin is a clinically important chemotherapeutical agent used to treat epithelial malignancies. High concentrations (20-100 microM) of cisplatin have been used in numerous studies to induce apoptosis of carcinoma cells grown in monolayer culture ... Read more...

Latest indexed articles for 'Tumor Suppressor Protein p53 - Metabolism'

These are the very latest articles for this heading:

• Runx2, p53, and pRB status as diagnostic parameters for deregulation of osteoblast growth and differentiation in a new pre-chemotherapeutic osteosarcoma cell line (OS1). 29 Nov 2009
• The reduction of cell death and proliferation by p27(Kip1) minimizes DNA damage in an experimental model of genotoxicity. 13 Nov 2009
• Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model. 13 Nov 2009
• Necdin: a multi functional protein with potential tumor suppressor role? 30 Oct 2009
• HPV-negative vulvar intraepithelial neoplasia (VIN) with basaloid histologic pattern: an unrecognized variant of simplex (differentiated) VIN. 30 Oct 2009
• Radiopathological characteristics of cerebellar malignant glioma in adults. 25 Oct 2009
• LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis. 29 Sep 2009
• Biological effects of high-energy neutrons measured in vivo using a vertebrate model. 29 Sep 2009
• Metabolic stabilization of p53 by FE65 in the nuclear matrix of osmotically stressed cells. 29 Sep 2009
• X-radiation induces non-small-cell lung cancer apoptosis by upregulation of Axin expression. 29 Sep 2009
• DN-R175H p53 mutation is more effective than p53 interference in inducing epithelial disorganization and activation of proliferation signals in human carcinoma cells: role of E-cadherin. 29 Sep 2009
• Parathyroid hormone-related protein confers chemoresistance by blocking apoptosis signaling via death receptors and mitochondria. 29 Sep 2009
• Effect of thioredoxin deletion and p53 cysteine replacement on human p53 activity in wild-type and thioredoxin reductase null yeast. 27 Sep 2009
• The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis. 25 Sep 2009
• p53--a Jack of all trades but master of none. 22 Sep 2009
• 20 years studying p53 functions in genetically engineered mice. 22 Sep 2009
• The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. 16 Sep 2009
• p53: a new kingpin in the stem cell arena. 16 Sep 2009
• MMR/c-Abl-dependent activation of ING2/p73alpha signaling regulates the cell death response to N-methyl-N'-nitro-N-nitrosoguanidine. 15 Sep 2009
• p53 and metabolism. 15 Sep 2009

See a longer list of these articles.

Technical information about 'Tumor Suppressor Protein p53'

Definition: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.

Registry Number: 0

Descriptor UI: D016159

Alternative terms: Tumor Suppressor Protein p53; Oncoprotein p53; TRP53 Protein; p53 Tumor Suppressor Protein; pp53 Phosphoprotein; Phosphoprotein, pp53; TP53 Protein; Cellular Tumor Antigen p53; p53 Antigen;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.260.820; D12.776.624.776.775; D12.776.660.825; D12.776.744.845;

History Note: 2005(1991);