Tyrosine 3-Monooxygenase - Genetics
Research News and Information

Sunday, November 22, 2009

The human insulin gene is part of a large open chromatin domain specific for human islets.

26 Sep 2009 Knowledge of how insulin (INS) gene expression is regulated will lead to better understanding of normal and abnormal pancreatic beta cell function. We have mapped histone modifications over the INS region, coupled with an expression profile, in ... Read more...

Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats.

15 Aug 2009 Viral vector-mediated gene transfer is emerging as a novel therapeutic approach with clinical utility in treatment of Parkinson's disease. Recombinant adeno-associated viral (rAAV) vector in particular has been utilized for continuous l-3,4 ... Read more...

Restriction of dopamine signaling to the dorsolateral striatum is sufficient for many cognitive behaviors.

8 Aug 2009 The striatum is a vital substrate for performance, procedural memory, and learning. The ventral and medial striatum are thought to be critical for acquisition of tasks while the dorsolateral striatum is important for performance and habitual ... Read more...

Latest indexed articles for 'Tyrosine 3-Monooxygenase - Genetics'

These are the very latest articles for this heading:

• The human insulin gene is part of a large open chromatin domain specific for human islets. 26 Sep 2009
• Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats. 15 Aug 2009
• Restriction of dopamine signaling to the dorsolateral striatum is sufficient for many cognitive behaviors. 8 Aug 2009
• gamma-Aminobutyric acid-mediated regulation of the activity-dependent olfactory bulb dopaminergic phenotype. 30 Jul 2009
• Age-dependent changes in noradrenergic locus coeruleus system in wild-type and APP23 transgenic mice. 21 Jul 2009
• cAMP-mediated stimulation of tyrosine hydroxylase mRNA translation is mediated by polypyrimidine-rich sequences within its 3'-untranslated region and poly(C)-binding protein 2. 18 Jul 2009
• MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development. 14 Jul 2009
• Functional consequences of genetic variation in primates on tyrosine hydroxylase (TH) expression in vitro. 6 Jul 2009
• Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons. 5 Jul 2009
• ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells. 4 Jul 2009
• Glucocorticoid status affects antidepressant regulation of locus coeruleus tyrosine hydroxylase and dorsal raphé tryptophan hydroxylase gene expression. Jul 2009
• Spectroscopy and kinetics of wild-type and mutant tyrosine hydroxylase: mechanistic insight into O2 activation. 8 Jun 2009
• Effect of dioxins on regulation of tyrosine hydroxylase gene expression by aryl hydrocarbon receptor: a neurotoxicology study. 4 Jun 2009
• Profound changes in dopaminergic neurotransmission in the prefrontal cortex in response to flattening of the diurnal glucocorticoid rhythm: implications for bipolar disorder. Jun 2009
• Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia. 31 May 2009
• TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia. 27 May 2009
• Psychosocial stress-related changes in gene expression of norepinephrine biosynthetic enzymes in stellate ganglia of adult rats. 21 May 2009
• Neuroimaging findings in children with paediatric neurotransmitter diseases. 18 May 2009
• Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia. 3 May 2009
• [Effect of electroacupuncture scalp point-through-point therapy on the expression of tyrosine hydroxylase and dopamine transporter mRNAs in substantia nigra of Parkinson's disease model rats] 29 Apr 2009

See a longer list of these articles.

Technical information about 'Tyrosine 3-Monooxygenase'

Definition: An enzyme that catalyzes the conversion of L-tyrosine, tetrahydrobiopterin, and oxygen to 3,4-dihydroxy-L-phenylalanine, dihydrobiopterin, and water. EC 1.14.16.2.

Chemical name: L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

Registry Number: EC 1.14.16.2

Descriptor UI: D014446

Alternative terms: Tyrosine 3-Monooxygenase; 3-Monooxygenase, Tyrosine; Tyrosine 3 Monooxygenase; Tyrosine Hydroxylase; Hydroxylase, Tyrosine;

Allowable Qualifiers: pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics;

Tree Number: D08.811.682.690.708.923; D12.776.556.579.374.925;

Online Note: use TYROSINE 3-MONOOXYGENASE to search TYROSINE HYDROXYLASE 1971-94 (as Prov 1971-73)

History Note: 95; was TYROSINE HYDROXYLASE 1971-94 (Prov 1971-73)