Ubiquitin-Protein Ligases - Metabolism
Research News and Information

Sunday, November 22, 2009

Carcinoma of the breast with medullary-like features: diagnostic challenges and relationship with BRCA1 and EZH2 functions.

30 Oct 2009 This case presentation reviews the histologic distinction between pure medullary carcinoma and breast carcinomas with medullary-like features. This particular case prompts us to analyze the relationship among medullary carcinoma, basal-like breast ... Read more...

Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice.

10 Oct 2009 The heterogeneous cellular composition of the mammalian renal collecting duct enables regulation of fluid, electrolytes, and acid-base homeostasis, but the molecular mechanism of its development has yet to be elucidated. The Notch signaling pathway ... Read more...

The BRCA1-dependent ubiquitin ligase, gamma-tubulin, and centrosomes.

29 Sep 2009 Mutation of the breast and ovarian cancer specific tumor suppressor, BRCA1, results in supernumerary and hyperactive centrosomes, which in turn likely contribute to the aneuploidy evident in breast cancer cells. The BRCA1-dependent ubiquitin ligase ... Read more...

Latest indexed articles for 'Ubiquitin-Protein Ligases - Metabolism'

These are the very latest articles for this heading:

• Carcinoma of the breast with medullary-like features: diagnostic challenges and relationship with BRCA1 and EZH2 functions. 30 Oct 2009
• Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. 10 Oct 2009
• The BRCA1-dependent ubiquitin ligase, gamma-tubulin, and centrosomes. 29 Sep 2009
• E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. 22 Sep 2009
• Identification of novel spartin-interactors shows spartin is a multifunctional protein. 14 Sep 2009
• Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. 12 Sep 2009
• Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA. 9 Sep 2009
• Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition. 8 Sep 2009
• CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53. 2 Sep 2009
• An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein. 31 Aug 2009
• Axin determines cell fate by controlling the p53 activation threshold after DNA damage. 30 Aug 2009
• E3 ubiquitin ligases in T-cell tolerance. 30 Aug 2009
• Neuralized-2: expression in human and rodents and interaction with Delta-like ligands. 29 Aug 2009
• Identification of X-DING-CD4, a new member of human DING protein family that is secreted by HIV-1 resistant CD4(+) T cells and has anti-viral activity. 27 Aug 2009
• The E3 ligase TRAF6 regulates Akt ubiquitination and activation. 26 Aug 2009
• Cell signaling. Blocking Akt-ivity. 26 Aug 2009
• Ubiquitin ligase ARF-BP1/Mule modulates base excision repair. 25 Aug 2009
• Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination. 25 Aug 2009
• Mind bomb 1 regulation of cFLIP interactions. 24 Aug 2009
• MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression. 24 Aug 2009

See a longer list of these articles.

Technical information about 'Ubiquitin-Protein Ligases'

Definition: A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.

Registry Number: EC 6.3.2.19

Descriptor UI: D044767

Alternative terms: Ubiquitin-Protein Ligases; Ligases, Ubiquitin-Protein; Ubiquitin Protein Ligases; Ubiquitin-Protein Ligase E3; Ligase E3, Ubiquitin-Protein; Ubiquitin Protein Ligase E3; Ubiquitin Ligase E3; E3, Ubiquitin Ligase; Ligase E3, Ubiquitin; Ubiquitin-Protein Ligase; Ligase, Ubiquitin-Protein; Ubiquitin Protein Ligase; E3 Ligase; Ligase, E3; E3 Ubiquitin Ligase; Ligase, E3 Ubiquitin; Ubiquitin Ligase, E3;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.464.938.750;

History Note: 2004; use UBIQUITIN-PROTEIN LIGASE (NM) 1983-2003

Technical Notes: UBIQUITIN-PROTEIN LIGASE COMPLEXES is also available