Ubiquitin-Protein Ligases
Research News and Information

Sunday, November 22, 2009

Carcinoma of the breast with medullary-like features: diagnostic challenges and relationship with BRCA1 and EZH2 functions.

30 Oct 2009 This case presentation reviews the histologic distinction between pure medullary carcinoma and breast carcinomas with medullary-like features. This particular case prompts us to analyze the relationship among medullary carcinoma, basal-like breast ... Read more...

Angelman syndrome: current understanding and research prospects.

30 Oct 2009 Angelman syndrome is a neurogenetic disorder characterized by developmental delay, severe intellectual disability, absent speech, exuberant behavior with happy demeanor, motor impairment, and epilepsy, due to deficient UBE3A gene expression that may ... Read more...

Attenuation of proteolysis-mediated cyclin E regulation by alternatively spliced Parkin in human colorectal cancers.

30 Oct 2009 Parkin has a critical role in the ubiquitin-proteasome system as an E3-ligase targeting several substrates. Our recent finding that Parkin-deficient mice are susceptible to tumorigenesis provided evidence that Parkin is a tumor suppressor gene. ... Read more...

Latest indexed articles for 'Ubiquitin-Protein Ligases'

These are the very latest articles for this heading:

• Carcinoma of the breast with medullary-like features: diagnostic challenges and relationship with BRCA1 and EZH2 functions. 30 Oct 2009
• Angelman syndrome: current understanding and research prospects. 30 Oct 2009
• Attenuation of proteolysis-mediated cyclin E regulation by alternatively spliced Parkin in human colorectal cancers. 30 Oct 2009
• Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. 10 Oct 2009
• Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. 2 Oct 2009
• The BRCA1-dependent ubiquitin ligase, gamma-tubulin, and centrosomes. 29 Sep 2009
• E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1. 22 Sep 2009
• Identification of novel spartin-interactors shows spartin is a multifunctional protein. 14 Sep 2009
• HECTD2, a candidate susceptibility gene for Alzheimer's disease on 10q. 13 Sep 2009
• Thermodynamic characterization of the folding equilibrium of the human Nedd4-WW4 domain: at the frontiers of cooperative folding. 13 Sep 2009
• Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. 12 Sep 2009
• Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA. 9 Sep 2009
• Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition. 8 Sep 2009
• CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53. 2 Sep 2009
• An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein. 31 Aug 2009
• [Influence of Tripterygium wilfordii on the expression of spermiogenesis related genes Herc4, Ipo11 and Mrto4 in mice] 30 Aug 2009
• Fluorescent oligonucleotides can serve as suitable alternatives to radiolabeled oligonucleotides. 30 Aug 2009
• Tumour suppression: Full on. 30 Aug 2009
• Axin determines cell fate by controlling the p53 activation threshold after DNA damage. 30 Aug 2009
• E3 ubiquitin ligases in T-cell tolerance. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Ubiquitin-Protein Ligases'

Definition: A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.

Registry Number: EC 6.3.2.19

Descriptor UI: D044767

Alternative terms: Ubiquitin-Protein Ligases; Ligases, Ubiquitin-Protein; Ubiquitin Protein Ligases; Ubiquitin-Protein Ligase E3; Ligase E3, Ubiquitin-Protein; Ubiquitin Protein Ligase E3; Ubiquitin Ligase E3; E3, Ubiquitin Ligase; Ligase E3, Ubiquitin; Ubiquitin-Protein Ligase; Ligase, Ubiquitin-Protein; Ubiquitin Protein Ligase; E3 Ligase; Ligase, E3; E3 Ubiquitin Ligase; Ligase, E3 Ubiquitin; Ubiquitin Ligase, E3;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.464.938.750;

History Note: 2004; use UBIQUITIN-PROTEIN LIGASE (NM) 1983-2003

Technical Notes: UBIQUITIN-PROTEIN LIGASE COMPLEXES is also available