Ubiquitination
Research News and Information

Sunday, November 22, 2009

Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells.

29 Nov 2009 Bone formation and osteoblast differentiation require the functional expression of the Runx2/Cbfbeta heterodimeric transcription factor complex. Runx2 is also a suppressor of proliferation in osteoblasts by attenuating cell cycle progression in ... Read more...

Structural basis for the lack of E2 interaction in the RING domain of TRAF2.

8 Nov 2009 TRAF proteins are intracellular signal transducers for a number of immune receptor superfamilies. Specifically, TRAF2 interacts with members of the TNF receptor superfamily and connects the receptors to downstream signaling proteins. It has been ... Read more...

Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival.

30 Oct 2009 In this study we examined whether established signal transduction cascades, p44/42 mitogen-activated protein kinase (ERK1/2) and Jun N-terminal kinases (JNK) pathways, are altered in N2a neural cells in response to proteasome inhibition. ... Read more...

Latest indexed articles for 'Ubiquitination'

These are the very latest articles for this heading:

• Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells. 29 Nov 2009
• Structural basis for the lack of E2 interaction in the RING domain of TRAF2. 8 Nov 2009
• Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival. 30 Oct 2009
• NDP52: the missing link between ubiquitinated bacteria and autophagy. 30 Oct 2009
• Involvement of a chromatin remodeling complex in damage tolerance during DNA replication. 23 Oct 2009
• Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling. 18 Oct 2009
• Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation. 10 Oct 2009
• The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. 9 Oct 2009
• Drug discovery: Propping up a destructive regime. 29 Sep 2009
• Ubiquitin-binding domains - from structures to functions. 29 Sep 2009
• Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement. 22 Sep 2009
• Destruction of RhoA CULtivates actin. 22 Sep 2009
• Linking the cell cycle to histone modifications: Dot1, G1/S, and cycling K79me2. 22 Sep 2009
• Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response. 19 Sep 2009
• Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. 14 Sep 2009
• Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5. 12 Sep 2009
• Listeria monocytogenes ActA-mediated escape from autophagic recognition. 11 Sep 2009
• Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination. 6 Sep 2009
• NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint. 4 Sep 2009
• Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. 4 Sep 2009

See a longer list of these articles.

Technical information about 'Ubiquitination'

Definition: The act of ligating UBIQUITINS to PROTEINS to form ubiquitin-protein ligase complexes to label proteins for transport to the PROTEASOME ENDOPEPTIDASE COMPLEX where proteolysis occurs.

Descriptor UI: D054875

Alternative terms: Ubiquitination; Ubiquitylation; Ubiquitinated Proteins; Protein, Ubiquitinated; Proteins, Ubiquitinated; Ubiquitinated Protein;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G02.111.087.875; G02.149.115.875; G03.495.955;

History Note: 2008