Ubiquitins
Research News and Information

Sunday, November 22, 2009

A distinct structural region of the prokaryotic ubiquitin-like protein (Pup) is recognized by the N-terminal domain of the proteasomal ATPase Mpa.

13 Sep 2009 The mycobacterial ubiquitin-like protein Pup is coupled to proteins, thereby rendering them as substrates for proteasome-mediated degradation. The Pup-tagged proteins are recruited by the proteasomal ATPase Mpa (also called ARC). Using a combination ... Read more...

F-box-directed CRL complex assembly and regulation by the CSN and CAND1.

9 Sep 2009 The COP9 signalosome (CSN) is thought to maintain the stability of cullin-RING ubiquitin ligases (CRL) by limiting the autocatalytic destruction of substrate adapters such as F box proteins (FBPs). CAND1, a protein associated with unneddylated CUL1, ... Read more...

Resolving the CSN and CAND1 paradoxes.

9 Sep 2009 In this issue of Molecular Cell, Schmidt et al. (2009) untangle the interplay between the COP9 signalosome (CSN), cullin-associated and neddylation-dissociated 1 (CAND1) protein, and cullin-RING ubiquitin ligases ... Read more...

Latest indexed articles for 'Ubiquitins'

These are the very latest articles for this heading:

• A distinct structural region of the prokaryotic ubiquitin-like protein (Pup) is recognized by the N-terminal domain of the proteasomal ATPase Mpa. 13 Sep 2009
• F-box-directed CRL complex assembly and regulation by the CSN and CAND1. 9 Sep 2009
• Resolving the CSN and CAND1 paradoxes. 9 Sep 2009
• Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein. 11 Aug 2009
• Atlantic cod (Gadus morhua L.) possesses three homologues of ISG15 with different expression kinetics and conjugation properties. 2 Aug 2009
• SUMOylation of nuclear actin. 25 Jul 2009
• DUBs at a glance. 13 Jul 2009
• The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. 12 Jul 2009
• Prokaryotic ubiquitin-like protein pup is intrinsically disordered. 12 Jul 2009
• Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity. 11 Jul 2009
• Development of a charcoal paper adenosine triphosphate:pyrophosphate exchange assay: kinetic characterization of NEDD8 activating enzyme. 10 Jul 2009
• Obscurin determines the architecture of the longitudinal sarcoplasmic reticulum. 5 Jul 2009
• Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses. 30 Jun 2009
• Protein ubiquitination in postsynaptic densities after hypoxia in rat neostriatum is blocked by hypothermia. 21 Jun 2009
• Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer. 7 Jun 2009
• Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization. 30 May 2009
• Comprehensive proteomic and transcriptomic analysis reveals early induction of a protective anti-oxidative stress response by low-dose proteasome inhibition. 30 May 2009
• NMR-derived solution structure of SUMO from Drosophila melanogaster (dSmt3). 30 May 2009
• Mechanical unfolding pathway and origin of mechanical stability of proteins of ubiquitin family: an investigation by steered molecular dynamics simulation. 30 May 2009
• Natural history of the E1-like superfamily: implication for adenylation, sulfur transfer, and ubiquitin conjugation. 30 May 2009

See a longer list of these articles.

Technical information about 'Ubiquitins'

Definition: A family of proteins that are structurally-related to Ubiquitin. Ubiquitins and ubiquitin-like proteins participate in diverse cellular functions, such as protein degradation and HEAT-SHOCK RESPONSE, by conjugation to other proteins.

Registry Number: 0

Descriptor UI: D014452

Alternative terms: Ubiquitins; Ubiquitin-Like Proteins; Proteins, Ubiquitin-Like; Ubiquitin Like Proteins;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.947;

History Note: 2002(1985);

Technical Notes: UBIQUITIN is available