Valine - Genetics
Research News and Information

Monday, November 23, 2009

N-terminal aliphatic residues dictate the structure, stability, assembly, and small molecule binding of the coiled-coil region of cartilage oligomeric matrix protein.

13 Sep 2009 The coiled-coil domain of cartilage oligomeric matrix protein (COMPcc) assembles into a homopentamer that naturally recognizes the small molecule 1,25-dihydroxyvitamin D(3) (vit D). To identify the residues critical for the structure, stability, ... Read more...

Structural effects of clinically observed mutations in JAK2 exons 13-15: comparison with V617F and exon 12 mutations.

8 Sep 2009 BACKGROUND: The functional relevance of many of the recently detected JAK2 mutations, except V617F and exon 12 mutants, in patients with chronic myeloproliferative neoplasia (MPN) has been significantly overlooked. To explore atomic-level ... Read more...

The functional Val158Met polymorphism of COMT predicts interindividual differences in brain alpha oscillations in young men.

31 Aug 2009 Individual patterns of the electroencephalogram (EEG) in wakefulness and sleep are among the most heritable traits in humans, yet distinct genetic and neurochemical mechanisms underlying EEG phenotypes are largely unknown. A functional polymorphism ... Read more...

Latest indexed articles for 'Valine - Genetics'

These are the very latest articles for this heading:

• N-terminal aliphatic residues dictate the structure, stability, assembly, and small molecule binding of the coiled-coil region of cartilage oligomeric matrix protein. 13 Sep 2009
• Structural effects of clinically observed mutations in JAK2 exons 13-15: comparison with V617F and exon 12 mutations. 8 Sep 2009
• The functional Val158Met polymorphism of COMT predicts interindividual differences in brain alpha oscillations in young men. 31 Aug 2009
• Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin: probing the active site of the enzyme with molecular modeling and site-directed mutagenesis. 21 Aug 2009
• Association between IRF6 SNPs and oral clefts in West China. 30 Jul 2009
• Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia. 26 Jul 2009
• Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children. 13 Jul 2009
• Analysis of the progression of JAK2 V617F positive myeloproliferative neoplasms by single-nucleotide polymorphism array does not reveal a strong chromosomal instability. 13 Jul 2009
• Controlling aggregation propensity in A53T mutant of alpha-synuclein causing Parkinson's disease. 2 Jul 2009
• BRAF V600E mutation analysis increases diagnostic accuracy for papillary thyroid carcinoma in fine-needle aspiration biopsies. 30 Jun 2009
• Identification of patients with poorer survival in primary myelofibrosis based on the burden of JAK2V617F mutated allele. 21 Jun 2009
• Alleviation of proteolytic sensitivity to enhance recombinant lipase production in Escherichia coli. 17 Jun 2009
• Catechol-O-methyltransferase valine(158)methionine polymorphism modulates brain networks underlying working memory across adulthood. 15 Jun 2009
• Drug consumption in medication overuse headache is influenced by brain-derived neurotrophic factor Val66Met polymorphism. 9 Jun 2009
• Development of a new genotyping assay for detection of the BDNF Val66Met polymorphism using melting-curve analysis. 30 May 2009
• Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase. 19 May 2009
• Prevalence of variant CJD in the UK. 19 May 2009
• Detection of a novel HLA-B27 allele, B*2740, in Taiwanese volunteer bone marrow donors by sequence-based typing: curiosity rewarded. 17 May 2009
• Effect of BDNF Val66Met polymorphism on digital working memory and spatial localization in a healthy Chinese Han population. 6 May 2009
• Association between catechol-O-methyltrasferase Val108/158Met genotype and prefrontal hemodynamic response in schizophrenia. 6 May 2009

See a longer list of these articles.

Technical information about 'Valine'

Definition: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.

Chemical name: Valine

Registry Number: 7004-03-7

Descriptor UI: D014633

Alternative terms: Valine; L-Valine; L Valine;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.125.070.950; D12.125.142.930;

Technical Notes: /biosyn /defic /physiol permitted