Valproic Acid - Adverse effects
Research News and Information

Monday, November 23, 2009

The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent?

30 Aug 2009 Juvenile myoclonic epilepsy is a common idiopathic generalized epileptic syndrome that includes generalized myoclonic seizures and commonly generalized tonic-clonic and generalized absence seizures. Before the emergence of the newer antiepileptic ... Read more...

Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis.

30 Jul 2009 OBJECTIVE: To determine whether valproic acid (VPA), a histone deacetylase inhibitor that showed antioxidative and antiapoptotic properties and reduced glutamate toxicity in preclinical studies, is safe and effective in amyotrophic lateral sclerosis ... Read more...

Divalproex sodium in children with partial seizures: 12-month safety study.

30 Jul 2009 This phase III, open-label, multicenter, outpatient study evaluated the 12-month safety of valproate using divalproex sodium sprinkle capsules for partial seizures, with or without secondary generalization, in children aged 3-10 years (n = 169). ... Read more...

Latest indexed articles for 'Valproic Acid - Adverse effects'

These are the very latest articles for this heading:

• [Correlation between renal tubular dysfunction and serum carnitine deficiency in cases with valproate therapy] 30 Aug 2009
• The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent? 30 Aug 2009
• Pregnancy treatment guidelines: throwing the baby out with the bath water. 30 Aug 2009
• Cognitive function after fetal exposure to antiepileptic drugs. 4 Aug 2009
• Epilepsy: Should valproate be avoided during childbearing years? 30 Jul 2009
• Randomized sequential trial of valproic acid in amyotrophic lateral sclerosis. 30 Jul 2009
• Divalproex sodium in children with partial seizures: 12-month safety study. 30 Jul 2009
• Valproic acid-induced myopathy in a patient with schizoaffective disorder. 30 Jul 2009
• Na VPA-induced acute ischemic stroke in an epileptic patient with methylenetetrahydrofolate reductase gene polymorphism. 28 Jul 2009
• Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model. 8 Jul 2009
• Valproate preparations for agitation in dementia. 6 Jul 2009
• Translation of randomised controlled trial findings into clinical practice: comparison of olanzapine and valproate in the EMBLEM study. 5 Jul 2009
• A case of fetal valproate syndrome with new features expanding the phenotype. 29 Jun 2009
• [Inadequate vasopressin secretion and valproate] 29 Jun 2009
• Stupor and fast activity on electroencephalography in a child treated with valproate. 29 Jun 2009
• Effectiveness of the first antiepileptic drug in the treatment of pediatric epilepsy. 29 Jun 2009
• Cognitive outcome after exposure to antiepileptic drugs in utero. 29 Jun 2009
• Topiramate in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register. 7 Jun 2009
• Pregnancy, delivery, and outcome for the child in maternal epilepsy. 30 May 2009
• [Hyperammonaemic encephalopathy due to valproic acid in the neonatal period] 30 May 2009

See a longer list of these articles.

Technical information about 'Valproic Acid'

Definition: A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.

Chemical name: Pentanoic acid, 2-propyl-

Registry Number: 99-66-1

Descriptor UI: D014635

Alternative terms: Valproic Acid; Acid, Valproic; 2-Propylpentanoic Acid; 2 Propylpentanoic Acid; Divalproex; Convulsofin; Depakene; Depakine; Depakote; Vupral; Divalproex Sodium; Sodium, Divalproex; Semisodium Valproate; Valproate, Semisodium; Valproic Acid, Sodium Salt (2:1); Ergenyl; Magnesium Valproate; Valproate, Magnesium; Sodium Valproate; Valproate, Sodium; Valproate Sodium; Sodium, Valproate; Valproate; Calcium Valproate; Valproate, Calcium; Dipropyl Acetate; Acetate, Dipropyl;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Antimanic Agents; Anticonvulsants; Enzyme Inhibitors; GABA Agents;

Tree Number: D02.241.081.944.509.900; D10.251.400.895.593.900;

Online Note: use VALPROIC ACID to search VALPROATE 1979-90 & DIPROPYL ACETATE 1975-90

History Note: 91; was VALPROATE 1979-90; was DIPROPYL ACETATE see under VALERATES 1975-78