Vascular Endothelial Growth Factor Receptor-1
Research News and Information

Monday, November 23, 2009

Vascular endothelial growth factor receptor-1 (VEGFR-1) expression in human corneal fibroblast decreased with age.

27 Sep 2009 PURPOSE: Mechanisms by which fibroblast networks between stromal lamellae are laid in the corneal stroma are far from clear. We have investigated the role of vascular endothelial growth factor receptors (VEGFRs) by in vitro studies in the human ... Read more...

Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways.

26 Sep 2009 Chronic inflammatory airway diseases including asthma are characterized by immune dysfunction to inhaled allergens. Our previous studies demonstrated that T cell priming to inhaled allergens requires LPS, which is ubiquitously present in household ... Read more...

Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature.

23 Sep 2009 Vascular functions of PlGF remain poorly understood and controversial. Here, we show that tumor cell-derived PlGF-1 and PlGF-2 displayed significant remodeling effects on the tumor vasculature, leading to a normalized vascular phenotype and improved ... Read more...

Latest indexed articles for 'Vascular Endothelial Growth Factor Receptor-1'

These are the very latest articles for this heading:

• Vascular endothelial growth factor receptor-1 (VEGFR-1) expression in human corneal fibroblast decreased with age. 27 Sep 2009
• Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways. 26 Sep 2009
• Malignant cell-derived PlGF promotes normalization and remodeling of the tumor vasculature. 23 Sep 2009
• VEGFR1-activity-independent metastasis formation. 15 Sep 2009
• Effects of CXCR4 antagonist CTCE-9908 on prostate tumor growth. 13 Sep 2009
• Impact of the transfer of sFlt-1 gene fragments on the ERK1/2 pathway of VEGF in vitro. 30 Aug 2009
• B-type natriuretic peptide enhances vasculogenesis by promoting number and functional properties of early endothelial progenitor cells. 30 Aug 2009
• A critical role for the IL-1 receptor in lung injury induced in neonatal rats by 60% O2. 30 Aug 2009
• Functional heterogeneity of the bone marrow vascular niche. 30 Aug 2009
• Local guidance of emerging vessel sprouts requires soluble Flt-1. 30 Aug 2009
• Expression of VEGF and VEGF receptors in childhood precursor B-cell acute lymphoblastic leukemia evaluated by immunohistochemistry. 30 Aug 2009
• Preoperative serum placenta growth factor level is a prognostic biomarker in colorectal cancer. 30 Aug 2009
• Gadd45a stress signaling regulates sFlt-1 expression in preeclampsia. 30 Aug 2009
• Growth factor receptor expression in anal squamous lesions: modifications associated with oncogenic human papillomavirus and human immunodeficiency virus. 25 Aug 2009
• Therapeutic targeting of the PDGF and TGF-beta-signaling pathways in hepatic stellate cells by PTK787/ZK22258. 8 Aug 2009
• VEGF receptor switching in heart development and disease. 2 Aug 2009
• Experimental ischaemia-reperfusion injury induces vascular endothelial growth factor expression in the rat testis. 30 Jul 2009
• Insights into angiogenic imbalances during pregnancy. 30 Jul 2009
• Placenta growth factor expression has prognostic value in malignant pleural mesothelioma. 30 Jul 2009
• Logical structures extracted from metastasis experiments. 27 Jul 2009

See a longer list of these articles.

Technical information about 'Vascular Endothelial Growth Factor Receptor-1'

Definition: A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.

Registry Number: EC 2.7.1.112

Descriptor UI: D040281

Alternative terms: Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor 1; FLT1 Receptor Tyrosine Kinase; VEGF Receptor flt-1 Protein; VEGF Receptor flt 1 Protein; VEGFR-1; fms-Like Tyrosine Kinase; Tyrosine Kinase, fms-Like; Proto-Oncogene Protein flt; Proto Oncogene Protein flt; FLT1 RTK; VEGF Receptor, FLT; FLT VEGF Receptor; Receptor, FLT VEGF;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D08.811.913.696.620.682.725.400.950.100; D12.776.543.750.060.750.100; D12.776.543.750.750.400.910.100;

History Note: 2003; use VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 (NM) 1990-2002; for FLK-1 RECEPTOR TYROSINE KINASE use RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR (NM) 1993-2002