 |
Wnt Proteins
Research News and Information
Definition of 'Wnt Proteins'Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN. Common names: Wnt Proteins; Wnt Factors; Wingless Type Proteins |
Sunday, November 22, 2009
29 Nov 2009 
Calcium/calmodulin-dependent protein kinase IV (CaMKIV) plays a key role in the regulation of calcium-dependent gene expression. The expression of CaMKIV and the activation of CREB regulated genes are involved in memory and neuronal survival. We ... Read more...
Role of Wnt inhibitory factor-1 and Wnt/wingless signaling in choroid plexus tumors.
29 Nov 2009 Little is known on pathways involved in the pathogenesis of choroid plexus tumors (CPTs). The finding of overexpression of Wnt inhibitory factor-1 (Wif-1) prompted us to investigate the functional role of Wif-1 as well as nuclear accumulation of ... Read more...
The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling.
Nov 2009 Wnt proteins bind to seven-transmembrane Frizzled receptors to mediate the important developmental, morphogenetic, and stem cell related tissue-regenerative effects of Wnt signaling. Dysregulated Wnt signaling is associated with many cancers. ... Read more...
Latest indexed articles for 'Wnt Proteins'
These are the very latest articles for this heading:
- Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway. 29 Nov 2009
- Role of Wnt inhibitory factor-1 and Wnt/wingless signaling in choroid plexus tumors. 29 Nov 2009
- The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Nov 2009
- Runx2 and bone morphogenic protein 2 regulate the expression of an alternative Lef1 transcript during osteoblast maturation. 30 Oct 2009
- Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. 14 Oct 2009
- Eyeing up new Wnt pathway players. 14 Oct 2009
- In pursuit of leucine-rich repeat-containing G protein-coupled receptor-5 regulation and function in the uterus. 29 Sep 2009
- Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. 29 Sep 2009
- Interactions with nanoscale topography: adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage. 29 Sep 2009
- Drug discovery: Propping up a destructive regime.
29 Sep 2009 - Tcf proteins are deeply rooted in skin. 29 Sep 2009
- Hedgehog activation is required upstream of Wnt signalling to control neural progenitor proliferation. 29 Sep 2009
- A directional Wnt/beta-catenin-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the Xenopus retina. 29 Sep 2009
- The posteriorizing gene Gbx2 is a direct target of Wnt signalling and the earliest factor in neural crest induction. 29 Sep 2009
- Towards an integrated view of Wnt signaling in development. 29 Sep 2009
- Pulsating fluid flow modulates gene expression of proteins involved in Wnt signaling pathways in osteocytes. 29 Sep 2009
- Methylation-associated silencing of SFRP1 with an 8p11-12 amplification inhibits canonical and non-canonical WNT pathways in breast cancers. 29 Sep 2009
- Notch activates Wnt-4 signalling to control medio-lateral patterning of the pronephros. 28 Sep 2009
- Increased neuronal proliferation in human bacterial meningitis. 27 Sep 2009
- Planar cell polarity and the kidney. 15 Sep 2009
See a longer list of these articles.
Technical information about 'Wnt Proteins'
Definition: Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.
Registry Number: 0
Descriptor UI: D051153
Alternative terms: Wnt Proteins; Wnt Factors; Wingless Type Proteins;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D12.644.276.984; D12.776.467.984; D23.529.984;
History Note: 2006(1987)