Genes, erbB-1 (Latest Articles)

Latest indexed articles for 'Genes, erbB-1'

Articles 1 to 10 of 200:

Amplification and expression of EGFR and ERBB2 in Wilms tumor.

13 Oct 2009 Wilms tumor is one of the most common solid tumors in children. We evaluated expression and amplification of a number of genes and their prognostic significance in 45 patients with Wilms tumor, using tissue microarray technology. The expression of ...
rec_pub_19781441-amplification-expression-egfr-erbb2-wilms-tumor.htm

DN-R175H p53 mutation is more effective than p53 interference in inducing epithelial disorganization and activation of proliferation signals in human carcinoma cells: role of E-cadherin.

29 Sep 2009 One of the hallmarks of carcinomas is epithelial disorganization, linked to overexpression of matrix metalloproteases (MMP) like MMP-9, loss of intercellular E-cadherin and activation of epidermal growth receptor (EGFR/erbB1). Since the p53 tumor ...
rec_pub_19507255-dn-r175h-p53-mutation-effective-p53-interference-inducing-epithelial.htm

Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts.

30 Aug 2009 PURPOSE: Concurrent temozolomide (TMZ) and radiation therapy (RT) followed by adjuvant TMZ is standard treatment for patients with glioblastoma multiforme (GBM), although the relative contribution of concurrent versus adjuvant TMZ is unknown. In ...
rec_pub_19695438-radiosensitizing-effects-temozolomide-observed-vivo-subset-o6.htm

Mucinous gastric carcinomas: clinicopathologic and molecular analyses.

30 Jul 2009 BACKGROUND: Mucinous gastric carcinoma (MGC) is characterized by substantial mucous lakes within tumors and comprises 3% of gastric carcinomas at the authors' institute. METHODS: The authors analyzed the clinicopathologic characteristics, mucin gene ...
rec_pub_19479974-mucinous-gastric-carcinomas-clinicopathologic-molecular-analyses.htm

Lack of association between common polymorphisms of epidermal growth factor receptors and nonsyndromic cleft lip with or without cleft palate.

29 Jun 2009 OBJECTIVES: Nonsyndromic cleft lip with or without cleft palate (CL/P) is a frequent craniofacial malformation with a complex aetiology. Since the first report of an association between DNA sequence variants at the transforming growth factor alpha ...
rec_pub_19307027-lack-association-common-polymorphisms-epidermal-growth-factor.htm

[Small-molecule tyrosine kinase inhibitors of epidermal growth factor receptor (EGFR)]

29 Jun 2009 Five years have passed since the activating mutation of the epidermal growth factor receptor (EGFR) gene was discovered. Patients with lung cancer harboring EGFR mutation respond remarkably well to small molecules, such as gefitinib or erlotinib, ...
rec_pub_19620791-small-molecule-tyrosine-kinase-inhibitors-epidermal-growth-factor.htm

Combined survival analysis of prospective clinical trials of gefitinib for non-small cell lung cancer with EGFR mutations.

14 Jun 2009 PURPOSE: Somatic mutations of the epidermal growth factor receptor (EGFR) gene are associated with an increased response to gefitinib in patients with non-small cell lung cancer. We have examined the impact of gefitinib on progression-free survival ...
rec_pub_19531624-combined-survival-analysis-prospective-clinical-trials-gefitinib-non.htm

Activating mutations within the EGFR kinase domain: a molecular predictor of disease-free survival in resected pulmonary adenocarcinoma.

9 Jun 2009 PURPOSE: Although epidermal growth factor receptor (EGFR) tyrosine kinase (TK) mutations are highly predictive of response to EGFR TK inhibitors in advanced non-small-cell lung cancer (NSCLC), a prognostic value of EGFR mutations in resected NSCLC ...
rec_pub_19517135-activating-mutations-egfr-kinase-domain-molecular-predictor-disease.htm

Role of the C-terminal linear region of EGF-like growth factors in ErbB specificity.

30 May 2009 The epidermal growth factor (EGF)-like growth factors bind their ErbB receptors in a highly selective manner. Recently, we have shown that the sequence YYDLL in the C-terminal linear region is compatible with binding to all ligand-binding ErbB ...
rec_pub_19384683-role-c-terminal-linear-region-egf-like-growth-factors-erbb-specificity.htm

Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer.

30 May 2009 BACKGROUND: The authors elucidated particular chemokine receptors that are expressed on lung cancer cells, as well as the clinical significance of the expression of these chemokine receptors in completely resected nonsmall cell lung cancer (NSCLC). ...
rec_pub_19309748-higher-expression-chemokine-receptor-cxcr7-linked-early-metastatic.htm

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