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Mice (Latest Articles)
Latest indexed articles for 'Mice'
Articles 1 to 10 of 200:
Genetic complexity of absence seizures in substrains of C3H mice.
15 Dec 2009 
Absence epilepsy is a common form of idiopathic generalized epilepsy whose etiology is poorly understood because of genetic and phenotypic heterogeneity. The inbred mouse strain C3H/He exhibits spontaneous absence seizures characterized by spike and ...
rec_pub_19170754-genetic-complexity-absence-seizures-substrains-c3h-mice.htm
13 Dec 2009 BACKGROUND: Ispinesib is a highly specific inhibitor of kinesin spindle protein (KSP, HsEg5), a mitotic kinesin required for separation of the spindle poles. Here we report the activity of ispinesib against the in vitro and in vivo panels of the ...
rec_pub_19554570-initial-testing-stage-1-kinesin-spindle-protein-inhibitor-ispinesib.htm
Mice mutant for genes associated with schizophrenia: common phenotype or distinct endophenotypes?
5 Dec 2009 Schizophrenia is a complex neuropsychiatric disorder whose etiology involves a mixture of genetic and environmental factors. By virtue of this complexity, schizophrenia is a field of research in which a number of key technologies converge: in ...
rec_pub_19728400-mice-mutant-genes-associated-schizophrenia-common-phenotype-distinct.htm
29 Nov 2009 Osteosarcomas are the most prevalent primary bone tumors found in pediatric patients. To understand their molecular etiology, cell culture models are used to define disease mechanisms under controlled conditions. Many osteosarcoma cell lines (e.g., ...
rec_pub_19746444-runx2-p53-prb-status-diagnostic-parameters-deregulation-osteoblast.htm
29 Nov 2009 Bone formation and osteoblast differentiation require the functional expression of the Runx2/Cbfbeta heterodimeric transcription factor complex. Runx2 is also a suppressor of proliferation in osteoblasts by attenuating cell cycle progression in ...
rec_pub_19739101-impaired-cell-cycle-regulation-osteoblast-related-heterodimeric.htm
Osteoblast differentiation is functionally associated with decreased AMP kinase activity.
29 Nov 2009 Osteoblasts, originating from mesenchymal stem cells, play a pivotal role in bone formation and mineralization. Several transcription factors including runt-related transcription factor 2 (Runx2) have been reported to be essential for osteoblast ...
rec_pub_19725053-osteoblast-differentiation-functionally-associated-decreased-amp.htm
29 Nov 2009 The expression profile and functions of the brain-enriched Rab22B/Rab31 small GTPase had remained uncharacterized. Using specific antibodies against Rab22B, we found the protein to be exceptionally enriched in nestin and RC2-positive radial glia of ...
rec_pub_19725050-rab22b-expressed-cns-astroglia-lineage-plays-role-epidermal-growth.htm
29 Nov 2009 The role of OxLDL in the generation and progression of atherosclerosis is well admitted. In addition, it is well known that atherosclerosis is often accompanied by perturbations in bone remodeling, resulting in osteoporosis. In the current studies, ...
rec_pub_19725047-oxidized-low-density-lipoprotein-decreases-rankl-induced.htm
29 Nov 2009 Calcium/calmodulin-dependent protein kinase IV (CaMKIV) plays a key role in the regulation of calcium-dependent gene expression. The expression of CaMKIV and the activation of CREB regulated genes are involved in memory and neuronal survival. We ...
rec_pub_19711354-calcium-calmodulin-dependent-protein-kinase-type-iv-target-gene-wnt.htm
Ceramide metabolism determines glioma cell resistance to chemotherapy.
29 Nov 2009 Tumor cell resistance to chemotherapy constitutes a major problem in the treatment of malignant tumors. We here investigated the role of ceramide metabolism for the resistance of glioma cells to treatment with the chemotherapeutic drug, gemcitabine. ...
rec_pub_19711353-ceramide-metabolism-determines-glioma-cell-resistance-chemotherapy.htm
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