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Synapses (Latest Articles)
Latest indexed articles for 'Synapses'
Articles 1 to 10 of 200:
Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling.
2 Nov 2009 
Activity-dependent alterations of synaptic contacts are crucial for synaptic plasticity. The formation of new dendritic spines and synapses is known to require actin cytoskeletal reorganization specifically during neural activation phases. Yet the ...
rec_pub_19890013-inositol-1-4-5-trisphosphate-3-kinase-functions-scaffold-synaptic-rac.htm
2 Nov 2009 The effects of lifelong, moderate excess release of glutamate (Glu) in the CNS have not been previously characterized. We created a transgenic (Tg) mouse model of lifelong excess synaptic Glu release in the CNS by introducing the gene for glutamate ...
rec_pub_19890003-transgenic-expression-glud1-glutamate-dehydrogenase-1-neurons-vivo.htm
Reliability and precision of the mouse calyx of Held synapse.
2 Nov 2009 Traditionally, the calyx of Held synapse is viewed as a highly reliable relay in the sound localization circuit of the auditory brainstem, with every presynaptic action potential triggering a postsynaptic action potential in vivo. However, this view ...
rec_pub_19889989-reliability-precision-mouse-calyx-held-synapse.htm
Aberrant expression of synaptic plasticity-related genes in the NF1+/- mouse hippocampus.
30 Oct 2009 Neurofibromatosis 1 (NF1) is a common single-gene disorder that causes learning impairments in patients. Neurofibromin encoded by the NF1 causal gene regulates Ras/MAPK and cAMP signaling pathways. These signaling pathways play critical roles in ...
rec_pub_19475561-aberrant-expression-synaptic-plasticity-related-genes-nf1-mouse.htm
30 Oct 2009 BACKGROUND: The memory-blocking properties of general anesthetics have recently received considerable attention because of concerns related to intraoperative awareness and postoperative cognitive dysfunction. The goal of this study was to identify ...
rec_pub_19809285-etomidate-targets-alpha5-gamma-aminobutyric-acid-subtype-receptors.htm
Metaplasticity governs natural experience-driven plasticity of nascent embryonic brain circuits.
27 Oct 2009 During embryogenesis, brain neurons receiving the same sensory input may undergo potentiation or depression. While the origin of variable plasticity in vivo is unknown, it plays a key role in shaping dynamic neural circuit refinement. Here, we ...
rec_pub_19874791-metaplasticity-governs-natural-experience-driven-plasticity-nascent.htm
ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses.
27 Oct 2009 The presynaptic active zone is composed of a protein network that contains ELKS2alpha (a.k.a. CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2alpha caused a large increase in inhibitory, but not excitatory, ...
rec_pub_19874790-elks2alpha-cast-deletion-selectively-increases-neurotransmitter.htm
19 Oct 2009 Pure NMDA receptor (NMDAr)-mediated EPSCs, thought to correspond to "silent" glutamatergic synapses that lack AMPA receptors (AMPArs), have been observed in superficial spinal dorsal horn of neonatal but not adult rats. Recent anatomical studies ...
rec_pub_19846727-evidence-ampa-receptor-lacking-glutamatergic-synapses-superficial.htm
19 Oct 2009 Homeostatic regulation of synaptic strength in response to persistent changes of neuronal activity plays an important role in maintaining the overall level of circuit activity within a normal range. Absence of miniature EPSCs (mEPSCs) for a few ...
rec_pub_19846710-endocannabinoid-dependent-homeostatic-regulation-inhibitory-synapses.htm
19 Oct 2009 
rec_pub_19846696-the-necessity-nkcc1-loss-chloride-cotransporter-knock-model-potential.htm
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