Tyrosine (Latest Articles)

Latest indexed articles for 'Tyrosine'

Articles 1 to 10 of 200:

Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval.

29 Nov 2009 ClC-2 chloride channel is present in the brain and some transporting epithelia where its function is poorly understood. We have now demonstrated that the surface channels are rapidly internalised and approximately the 70% of the surface membrane ...
rec_pub_19711355-rapid-recycling-clc-2-chloride-channels-plasma-membrane-endosomes.htm

Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking.

27 Oct 2009 Modification of NMDA receptor function and trafficking contributes to the regulation of synaptic transmission and is important for several forms of synaptic plasticity. Here, we report that NMDA receptor subunits NR2A and NR2B have two distinct ...
rec_pub_19874789-dual-palmitoylation-nr2-subunits-regulates-nmda-receptor-trafficking.htm

Real time monitoring of sickle cell hemoglobin fiber formation by UV resonance Raman spectroscopy.

18 Oct 2009 In sickle cell hemoglobin, individual tetramers associate into long fibers as a consequence of the mutation at the beta6 position. In this study UV resonance Raman spectroscopy is used to monitor the formation of Hb S fibers in real time through ...
rec_pub_19778007-real-time-monitoring-sickle-cell-hemoglobin-fiber-formation-uv.htm

Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.

10 Oct 2009 Mutations in the neuronal protein alpha-synuclein cause familial Parkinson disease. Phosphorylation of alpha-synuclein at serine 129 is prominent in Parkinson disease and influences alpha-synuclein neurotoxicity. Here we report that alpha-synuclein ...
rec_pub_19855133-tyrosine-serine-phosphorylation-alpha-synuclein-opposing-effects.htm

Proteomic and genetic approaches identify Syk as an AML target.

4 Oct 2009 Cell-based screening can facilitate the rapid identification of compounds inducing complex cellular phenotypes. Advancing a compound toward the clinic, however, generally requires the identification of precise mechanisms of action. We previously ...
rec_pub_19800574-proteomic-genetic-approaches-identify-syk-aml-target.htm

Can treating the SYK cell cure leukemia?

4 Oct 2009 Targeted therapy has remained elusive for most acute myeloid leukemia patients. In this issue of Cancer Cell, Stegmaier and colleagues identify SYK as a key mediator of the differentiation block seen in this disease. Their data suggest that SYK ...
rec_pub_19800569-can-treating-syk-cell-cure-leukemia.htm

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation.

29 Sep 2009 DYRK1A is a dual-specificity protein kinase that autophosphorylates a conserved tyrosine residue in the activation loop but phosphorylates exogenous substrates only at serine or threonine residues. Tyrosine autophosphorylation of DYRKs is a one-off ...
rec_pub_19796173-harmine-specifically-inhibits-protein-kinase-dyrk1a-interferes.htm

PYK2/PDZ-RhoGEF links Ca2+ signaling to RhoA.

29 Sep 2009 OBJECTIVE: Ras homolog gene family member A (RhoA)/Rho-kinase-mediated Ca(2+) sensitization is a critical component of constrictor responses. The present study investigates how angiotensin II activates RhoA. METHODS AND RESULTS: Adenoviral vectors ...
rec_pub_19759375-pyk2-pdz-rhogef-links-ca2-signaling-rhoa.htm

Signal transduction responses to lysophosphatidic acid and sphingosine 1-phosphate in human prostate cancer cells.

29 Sep 2009 BACKGROUND: Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are lipid mediators that bind to G-protein-coupled receptors. In this study, signaling responses to 18:1 LPA and S1P were examined in parallel in three human prostate cancer ...
rec_pub_19536794-signal-transduction-responses-lysophosphatidic-acid-sphingosine-1.htm

Binding of DC-HIL to dermatophytic fungi induces tyrosine phosphorylation and potentiates antigen presenting cell function.

28 Sep 2009 APCs express receptors recognizing microbes and regulating immune responses by binding to corresponding ligands on immune cells. Having discovered a novel inhibitory pathway triggered by ligation of DC-HIL on APC to a heparin/heparan sulfate-like ...
rec_pub_19794069-binding-dc-hil-dermatophytic-fungi-induces-tyrosine-phosphorylation.htm

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