Base Sequence (Latest Articles)

Latest indexed articles for 'Base Sequence'

Articles 121 to 130 of 200:

Time-resolved RNA SHAPE chemistry: quantitative RNA structure analysis in one-second snapshots and at single-nucleotide resolution.

8 Sep 2009 RNA selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE) chemistry exploits the discovery that conformationally dynamic nucleotides preferentially adopt configurations that facilitate reaction between the 2'-OH group and a ...
rec_pub_19745823-time-resolved-rna-shape-chemistry-quantitative-rna-structure-analysis.htm

Identification of specific small molecule ligands for stem loop 3 ribonucleic acid of the packaging signal Psi of human immunodeficiency virus-1.

8 Sep 2009 We have screened the NCI diversity set library for molecules that bind specifically to stem loop 3 (SL3) RNA of the packaging element Psi of HIV-1 using the docking programs DOCK and AutoDock, followed by MD simulations. The association of the ...
rec_pub_19691339-identification-specific-small-molecule-ligands-stem-loop-3.htm

The nucleoside analogue D-carba T blocks HIV-1 reverse transcription.

8 Sep 2009 A major pathway for HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs) involves reverse transcriptase (RT) mutations that enhance ATP-dependent pyrophosphorolysis, which excises NRTIs from the end of viral DNA. We analyzed novel ...
rec_pub_19678643-the-nucleoside-analogue-d-carba-t-blocks-hiv-1-reverse-transcription.htm

A novel decoy that interrupts G93A-superoxide dismutase gain of interaction with malate dehydrogenase improves survival in an amyotrophic lateral sclerosis cell model.

8 Sep 2009 Human G93A-superoxide dismutase-1 (G93AhSOD1) mutation causes amyotrophic lateral sclerosis (ALS) in rodents and humans. Recent observations indicate gain of interaction of G93AhSOD1 with cytosolic malate dehydrogenase (MDH1) and subsequent ...
rec_pub_19670830-a-novel-decoy-interrupts-g93a-superoxide-dismutase-gain-interaction.htm

Studies of the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells.

8 Sep 2009 We have examined the biological activity of 12 platinum(II)-based DNA intercalators of the type [Pt(I(L))(A(L))](2+), where I(L) is an intercalating ligand (1,10-phenanthroline or a methylated derivative) and A(L) is an ancillary ligand ...
rec_pub_19658404-studies-mechanism-action-platinum-ii-complexes-potent-cytotoxicity.htm

Hepatocyte nuclear factor 1 is essential for transcription of sodium-dependent vitamin C transporter protein 1.

7 Sep 2009 Transport and distribution of vitamin C is primarily regulated by the function of sodium-dependent vitamin C transporters (SVCTs). SVCT1 is expressed in the small intestine, liver, and kidney, organs that play a vital role in whole body vitamin C ...
rec_pub_19741195-hepatocyte-nuclear-factor-1-essential-transcription-sodium-dependent.htm

Effect of iron on cytolysin A expression in Salmonella enterica serovar Typhi.

7 Sep 2009 Previously, a novel protein ClyA (Cytolysin A) has been identified in Escherichia coli K-12, Salmonella enterica serovars Typhi and Paratyphi A and Shigella. Salmonella spp. synthesize substantial amounts of ClyA upon infection of the human host, ...
rec_pub_19763423-effect-iron-cytolysin-expression-salmonella-enterica-serovar-typhi.htm

Cloning and molecular characterization of a novel rolling-circle replicating plasmid, pK1S-1, from Bacillus thuringiensis subsp. kurstaki K1.

7 Sep 2009 Bacillus thuringiensis, an entomopathogenic bacterium belonging to the B. cereus group, harbors numerous extra-chromosomal DNA molecules whose sizes range from 2 to 250 kb. In this study, we used a plasmid capture system (PCS) to clone three small ...
rec_pub_19763421-cloning-molecular-characterization-novel-rolling-circle-replicating.htm

Analysis of FUS gene mutation in familial amyotrophic lateral sclerosis within an Italian cohort.

7 Sep 2009 OBJECTIVE: Mutations in the FUS gene on chromosome 16 have been recently discovered as a cause of familial amyotrophic lateral sclerosis (FALS). This study determined the frequency and identities of FUS gene mutations in a cohort of Italian patients ...
rec_pub_19741215-analysis-fus-gene-mutation-familial-amyotrophic-lateral-sclerosis.htm

Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation.

6 Sep 2009 The zinc-finger PR domain transcriptional repressor Blimp-1/Prdm1 plays essential roles in primordial germ cell specification, placental, heart, and forelimb development, plasma cell differentiation, and T-cell homeostasis. The present experiments ...
rec_pub_19737919-blimp-1-prdm1-alternative-promoter-usage-mouse-development-plasma.htm

Results: [1-10] [11-20] [21-30] [31-40] [41-50] [51-60] [61-70] [71-80] [81-90] [91-100] [101-110] [111-120] [121-130] [131-140] [141-150] [151-160] [161-170] [171-180] [181-190] [191-200]