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Computer Simulation (Latest Articles)

 

Latest indexed articles for 'Computer Simulation'

Articles 81 to 90 of 200:

M-quantile regression analysis of temporal gene expression data.

20 Sep 2009 In this paper, we explore the use of M-quantile regression and M-quantile coefficients to detect statistical differences between temporal curves that belong to different experimental conditions. In particular, we consider the application of temporal ...
rec_pub_19799560-m-quantile-regression-analysis-temporal-gene-expression-data.htm


Modeling dependence in methylation patterns with application to ovarian carcinomas.

20 Sep 2009 Changes in cytosine methylation at CpG nucleotides are observed in many cancers and offer great potential for translational research. Diseases such as ovarian cancer that are especially challenging to diagnose and treat are of particular interest, ...
rec_pub_19799559-modeling-dependence-methylation-patterns-application-ovarian.htm


Declines in acute myocardial infarction after smoke-free laws and individual risk attributable to secondhand smoke.

19 Sep 2009 BACKGROUND: The estimated effects of recent pubic and workplace smoking restriction laws suggest that they produce significant declines in community rates of heart attack. The consistency of these declines with existing estimates of the relative ...
rec_pub_19770392-declines-acute-myocardial-infarction-smoke-free-laws-individual-risk.htm


Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms.

18 Sep 2009 Biological pathways are structured in complex networks of interacting genes. Solving the architecture of such networks may provide valuable information, such as how microorganisms cause disease. Here we present a method (Tn-seq) for accurately ...
rec_pub_19767758-tn-seq-high-throughput-parallel-sequencing-fitness-genetic.htm


An information-theoretical approach to phylogeography.

16 Sep 2009 Data analysis in phylogeographic investigations is typically conducted in either a qualitative manner, or alternatively via the testing of null hypotheses. The former, where inferences about population processes are derived from geographical ...
rec_pub_19765225-an-information-theoretical-approach-phylogeography.htm


Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress.

16 Sep 2009 Oxidative stress with hydrogen peroxide (H(2)O(2)) readily promotes early afterdepolarizations (EADs) and triggered activity (TA) in isolated rat and rabbit ventricular myocytes. Here we examined the effects of H(2)O(2) on arrhythmias in intact ...
rec_pub_19767530-increased-susceptibility-aged-hearts-ventricular-fibrillation.htm


The impact of population size on the evolution of asexual microbes on smooth versus rugged fitness landscapes.

16 Sep 2009 BACKGROUND: It is commonly thought that large asexual populations evolve more rapidly than smaller ones, due to their increased rate of beneficial mutations. Less clear is how population size influences the level of fitness an asexual population can ...
rec_pub_19765292-the-impact-population-size-evolution-asexual-microbes-smooth-versus.htm


Details of insect wing design and deformation enhance aerodynamic function and flight efficiency.

16 Sep 2009 Insect wings are complex structures that deform dramatically in flight. We analyzed the aerodynamic consequences of wing deformation in locusts using a three-dimensional computational fluid dynamics simulation based on detailed wing kinematics. We ...
rec_pub_19762645-details-insect-wing-design-deformation-enhance-aerodynamic-function.htm


Three-dimensional structural view of the central metabolic network of Thermotoga maritima.

16 Sep 2009 Metabolic pathways have traditionally been described in terms of biochemical reactions and metabolites. With the use of structural genomics and systems biology, we generated a three-dimensional reconstruction of the central metabolic network of the ...
rec_pub_19762644-three-dimensional-structural-view-central-metabolic-network.htm


Calculating asymptotic significance levels of the constrained likelihood ratio test with application to multivariate genetic linkage analysis.

15 Sep 2009 The asymptotic distribution of the multivariate variance component linkage analysis likelihood ratio test has provoked some contradictory accounts in the literature. In this paper we confirm that some previous results are not correct by deriving the ...
rec_pub_19799558-calculating-asymptotic-significance-levels-constrained-likelihood.htm

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