Research article summary (published 30 Jan 1999):

Involvement of rodent prefrontal cortex subregions in strategy switching.

Full Abstract

The present study examined whether inactivation of the prelimbic-infralimbic areas or the dorsal anterior cingulate area impairs strategy switching in the cheeseboard task. After implantation of a cannula aimed at either the prelimbic-infralimbic or dorsal anterior cingulate areas, all rats were tested in a spatial and a visual-cued version of the task. Some of the rats received the spatial version first, followed by the visual-cued version. The procedure for the other rats was reversed. Infusions of 2% tetracaine into the prelimbic-infralimbic or dorsal anterior cingulate areas did not impair acquisition of the spatial or visual-cued versions. However, inactivation of the prelimbic-infralimbic areas, but not the dorsal anterior cingulate area, impaired learning when rats were switched from one version to the other. These findings suggest that the prelimbic-infralimbic areas are involved in switching to new behavior-guiding strategies.

Author information

Author/s: Ragozzino, M E (ME); Wilcox, C (C); Raso, M (M); Kesner, R P (RP);

Affiliation: Department of Psychology, University of Utah, Salt Lake City 84112, USA.

Grants: R01NS20771-12 (Agency:NINDS NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal: Behavioral neuroscience (Behav Neurosci), published in UNITED STATES. (Language: eng)

Reference: 1999-Feb; vol 113 (issue 1) : pp 32-41

Dates: Created 1999/07/16; Completed 1999/07/16; Revised 2007/11/14;

PMID: 10197904, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Appetitive Behavior - physiology Attention - physiology Brain Mapping Cues Gyrus Cinguli - physiology Limbic System - physiology

Male Orientation - physiology Prefrontal Cortex - physiology Problem Solving - physiology Rats Rats, Long-Evans Visual Perception - physiology

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