Elevated serum leptin concentrations in type 2 diabetic patients with microalbuminuria and macroalbuminuria.

Full Abstract

Leptin levels are elevated in end-stage renal disease, suggesting an impairment of renal leptin degradation. The present study aimed to determine whether leptin levels are also elevated in patients with earlier stages of renal disease, ie, microalbuminuric and macroalbuminuric nephropathy. A total of 60 subjects were assigned to two study groups. Group A contained 10 type 2 diabetics with macroalbuminuria, 10 type 2 diabetics with normoalbuminuria, and 10 healthy control subjects. Group B contained 10 type 2 diabetics with microalbuminuria, 10 type 2 diabetics with normoalbuminuria, and 10 healthy controls. The subgroups of both study groups were matched for sex and body fatness. In group A, macroalbuminuric diabetic patients had higher serum leptin levels than the normoalbuminuric diabetics (11.90 +/- 2.98 v 4.13 +/- 0.92 ng/mL, P < .002) and control subjects (4.78 +/- 1.37 ng/mL, P < .006). In group B, microalbuminuric diabetics had higher serum leptin levels than the normoalbuminuric diabetics (21.16 +/- 5.80 v8.74 +/- 1.89 ng/mL, P < .04) and control subjects (10.06 + 3.00 ng/mL, P < .06). In both groups A and B, creatinine clearance was inversely correlated with the serum leptin level after adjusting for body fat. In conclusion, serum leptin levels are elevated in type 2 diabetic patients with microalbuminuria and macroalbuminuria, suggesting that renal leptin degradation is already impaired in the early stages of renal disease.

Author information

Author/s: Fruehwald-Schultes, B (B); Kern, W (W); Beyer, J (J); Forst, T (T); Pfützner, A (A); Peters, A (A);

Affiliation: Department of Internal Medicine 1, Medical University of Luebeck, Germany.

Journal and publication information

Publication Type: Journal Article

Journal: Metabolism: clinical and experimental (Metabolism), published in UNITED STATES. (Language: eng)

Reference: 1999-Oct; vol 48 (issue 10) : pp 1290-3

Dates: Created 1999/11/05; Completed 1999/11/05; Revised 2006/11/15;

PMID: 10535393, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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