Research article summary (published 29 Sep 1999):

The discriminative stimulus properties of LY233708, a selective serotonin reuptake inhibitor, in the pigeon.

Full Abstract

RATIONALE: Understanding the contribution of the various serotonin (5-HT) receptor subtypes to the behavioral effects of selective serotonin reuptake inhibitors (SSRIs) may contribute to the discovery of increasingly effective drugs for the treatment of conditions such as depression, panic and obsessive-compulsive disorders. OBJECTIVES: A drug discrimination procedure was used to determine whether the administration of an SSRI was associated with a specific interoceptive stimulus cue and to what extent that cue was related to activation of the 5-HT(1A) receptor. METHOD: Pigeons were trained to discriminate 20 mg/kg of the short acting, SSRI, LY233708 dihydrochloride dihydrate [(-)-cis-1-(6-chloro-1,2,3,4- tetrahydro-1-methyl-2-naphthalenyl)piperazine] from saline. RESULTS: LY233708 induced a specific, dose-related stimulus cue. The SSRIs, fluoxetine and citalopram, induced dose-related responding on the LY233708-associated key. In contrast, nisoxetine, a selective norepinephrine uptake inhibitor, induced responding on the saline-associated key. The prototypical 5-HT(1A) agonist, 8-OH-DPAT [8-hydroxy-(2-di-n-propylamino)tetralin] substituted for LY233708. This generalization was blocked by the selective 5-HT(1A) antagonist, WAY-100635 [N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexanecarboxamide]. CONCLUSION: These data demonstrate that an SSRI can induce a specific, stable discriminative stimulus that appears to involve activation of the 5-HT(1A) receptor in the pigeon.

Author information

Author/s: Wolff, M C (MC); Leander, J D (JD);

Affiliation: Lilly Research Laboratories, Eli Lilly and Company, Mail Code No. 0510, Lilly Corporate Center, Indianapolis, IN 46285, USA. wolff_mary_c(-atsign-)lilly.com

Journal and publication information

Publication Type: Journal Article

Journal: Psychopharmacology (Psychopharmacology (Berl)), published in GERMANY. (Language: eng)

Reference: 1999-Oct; vol 146 (issue 3) : pp 275-9

Dates: Created 1999/12/15; Completed 1999/12/15; Revised 2004/11/17;

PMID: 10541727, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Animals Columbidae Cues Discrimination Learning - drug effects

Dose-Response Relationship, Drug Male Piperazines - pharmacology Pyridines - pharmacology Serotonin Uptake Inhibitors - pharmacology

Associated Chemicals: LY233708 (0) ; Piperazines (0) ; Pyridines (0) ; Serotonin Uptake Inhibitors (0) ; WAY 100635 (146714-97-8) ; 8-Hydroxy-2-(di-n-propylamino)tetralin (78950-78-4)

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