Research article summary (published 30 Mar 2000):

Psychiatric phenomenology of child and adolescent bipolar offspring.

Full Abstract

OBJECTIVE: To establish prodromal signs of and risk factors for childhood bipolar disorder (BD) by characterizing youths at high risk for BD. METHOD: Structured diagnostic interviews were performed on 60 biological offspring of at least one parent with BD. Demographics, family histories, and parental history of childhood disruptive behavioral disorders were also assessed. RESULTS: Fifty-one percent of bipolar offspring had a psychiatric disorder, most commonly attention-deficit/hyperactivity disorder (ADHD), major depression or dysthymia, and BD. BD in offspring tended to be associated with earlier parental symptom onset when compared with offspring without a psychiatric diagnosis. Bipolar parents with a history of childhood ADHD were more likely to have children with BD, but not ADHD. Offspring with bilineal risk had increased severity of depressed and irritable mood, lack of mood reactivity, and rejection sensitivity, while severity of grandiosity, euphoric mood, and decreased need for sleep were not preferentially associated with such offspring. CONCLUSIONS: Bipolar offspring have high levels of psychopathology. Parental history of early-onset BD and/or childhood ADHD may increase the risk that their offspring will develop BD. Prodromal symptoms of childhood BD may include more subtle presentations of mood regulation difficulties and less presence of classic manic symptoms.

Author information

Author/s: Chang, K D (KD); Steiner, H (H); Ketter, T A (TA);

Affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305-5540, USA. kchang88(-atsign-)stanford.edu

Grants: 5 T32 MH19908-03 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal: Journal of the American Academy of Child and Adolescent Psychiatry (J Am Acad Child Adolesc Psychiatry), published in UNITED STATES. (Language: eng)

Reference: 2000-Apr; vol 39 (issue 4) : pp 453-60

Dates: Created 2000/05/03; Completed 2000/05/03; Revised 2007/11/14;

PMID: 10761347, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent Age Factors Attention Deficit Disorder with Hyperactivity - complications; genetics Bipolar Disorder - complications; epidemiology; genetics; psychology Child Comorbidity Female Genetic Predisposition to Disease - epidemiology; psychology

Humans Male Mood Disorders - diagnosis Prevalence Psychiatric Status Rating Scales Risk Factors Sampling Studies Sex Factors

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