Research article summary (published 30 Mar 2000):

Prolonged stationary colonic motility recording in seven patients with severe constipation secondary to antidepressants.

Full Abstract

The aim of this study was to determine whether the colonic motor profile of seven patients with constipation secondary to antidepressants differed from the motility of seven patients with idiopathic constipation and seven healthy volunteers. All constipated patients had very severe constipation. Colonic manometric recordings were performed for 24 h. The number of high amplitude propagating contractions (HAPC) was lower in the two groups of constipated patients than in controls. No HAPC were observed in 5/7 patients with constipation secondary to antidepressants and in 1/7 patients with idiopathic constipation. The overall area under the curve (AUC) in the left colon was lower in the two constipated patient groups than in controls. AUC increased after a 1000-kcal standard meal given at noon in controls but not in the two groups of constipated patients. In conclusion, in patients with constipation secondary to antidepressants, the overall AUC was as poor as in patients with idiopathic constipation, and no colonic response to eating was observed. Moreover, the number of HAPC was more markedly decreased in patients with constipation secondary to antidepressants than in patients with idiopathic constipation.

Author information

Author/s: Leroi, A M (AM); Lalaude, O (O); Antonietti, M (M); Touchais, J Y (JY); Ducrotte, P (P); Menard, J F (JF); Denis, P (P);

Affiliation: Groupe de Recherche sur l'Appareil Digestif, Policlinique, Hôpital Charles Nicolle, Rouen, France.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (Neurogastroenterol Motil), published in ENGLAND. (Language: eng)

Reference: 2000-Apr; vol 12 (issue 2) : pp 149-54

Dates: Created 2000/06/26; Completed 2000/06/26; Revised 2006/11/15;

PMID: 10771496, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Neurogastroenterol Motil. 2000 Apr;12(2):113-5. (PMID: 10771493)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Amitriptyline - adverse effects; pharmacology; therapeutic use Antidepressive Agents - adverse effects; pharmacology; therapeutic use Anxiety Disorders - complications Cathartics - therapeutic use Cholinergic Antagonists - adverse effects; pharmacology; therapeutic use Clomipramine - adverse effects; pharmacology; therapeutic use Colon - drug effects; physiopathology Colonoscopy Constipation - chemically induced; drug therapy; physiopathology Depressive Disorder - complications; drug therapy Eating Fecal Impaction - chemically induced; drug therapy; physiopathology

Female Gastrointestinal Motility - drug effects Humans Male Manometry Maprotiline - adverse effects; pharmacology; therapeutic use Middle Aged Mood Disorders - complications Muscle Contraction Paroxetine - adverse effects; pharmacology; therapeutic use Serotonin Uptake Inhibitors - adverse effects; pharmacology; therapeutic use Thiazepines - adverse effects; pharmacology; therapeutic use Viloxazine - adverse effects; pharmacology; therapeutic use

Associated Chemicals: Antidepressive Agents (0) ; Cathartics (0) ; Cholinergic Antagonists (0) ; Serotonin Uptake Inhibitors (0) ; Thiazepines (0) ; Maprotiline (10262-69-8) ; Clomipramine (303-49-1) ; Viloxazine (46817-91-8) ; Amitriptyline (50-48-6) ; Paroxetine (61869-08-7) ; tianeptine (66981-73-5)

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